摘要
目的 评价针灸联合金天格胶囊治疗腰椎间盘突出症（lumbar disc herniation, LDH）的疗效。方法 将符合入选标准的95例LDH患者，采用随机数字表法分为对照组47例和研究组48例。对照组采用针灸治疗，研究组在对照组基础上口服金天格胶囊。2组均治疗4周为1个疗程，连续治疗3个疗程。采用VAS量表评价患者的疼痛程度，采用日本骨科协会评分（Japanese Orthopedic Association Scores, JOA）评价腰椎功能；采用ELISA法检测血清TNF-a、IL-1β、IL-6和血栓素B2（thromboxane, TXB2）水平，观察并记录患者症状控制时间、直腿抬高角度，评价临床疗效。结果 研究组总有效率为93.8%（45/48）、对照组为76.6%（36/47），2组比较差异有统计学意义（χ2＝5.562，P＝0.018）。研究组症状控制时间[（9.2±2.3）d比（14.0±2.3）d，t＝-10.406]短于对照组（P＜0.05）。治疗后，研究组直腿抬高角度[（78.6±17.6）°比（59.9±13.2）°，t＝5.869]及JOA评分[（18.7±2.1）分比（12.1±1.9）分，t＝16.152]高于对照组（P＜0.01），VAS评分[（1.1±0.3）分比（2.6±0.6）分，t＝-15.997]、TNF-a[（1.18±0.22）ng/L比（1.51±0.21）ng/L，t＝-7.476]、IL-1β[（25.14±6.17）ng/ml比（40.26±6.07）ng/ml，t＝-12.038]、IL-6[（93.85±23.02）μg/L比（110.63±24.07）μg/L，t＝-3.473]及TXB2[（299.36±52.16）pg/ml比（429.17±53.62）pg/ml，t＝-11.961]低于对照组（P＜0.01）。结论 针灸联合金天格胶囊可有效改善LDH患者疼痛程度，降低血清炎性细胞因子水平，提高临床疗效。
Objective To explore the clinical efficacy and safety of acupuncture combined with Jintiange capsule for the patients with lumbar disc herniation （LDH）. Methods According to the random table method, 95 cases of patients with LDH were divided into the control group （n=47） and the research group （n=48） from June 2015 to March 2017. The patients in the control group were treated by acupuncture, while the patients in the research group were treated with Jintiange capsule on the basis of the control group. The continuous treatment for 4 weeks was a course, and the treatment of two groups was 2 courses. The clinical total effective rate and symptom control time of two groups were observed. The pain intensity, JOA, the straight leg-raising angle and the serum level of inflammatory factors of two groups of patients were detected before and after treatment respectively. In addition, the incidence of adverse reactions of two groups was analyzed. Results The total clinical effectiveness of the research group was 93.75% （45/48）, and the control group was 76.60% （36/47）. The difference of two groups was statistically significant （χ2=5.562, P=0.018）. The symptom control time （9.2 ± 2.3 d vs. 14.0 ± 2.3 d, t=-10.406） of the research group was significantly lower than that of the control group （P〈0.05）. After treatment, the straight leg-raising angle [（78.6 ± 17.6）° vs. （59.9 ± 3.2）°, t=5.869] and JOA （18.7 ± 2.1 vs. 12.1 ± 1.9, t=16.152） of research group was significantly higher than those of the control group. While the VAS score （1.1 ± 0.3 vs. 2.6 ± 0.6, t=-15.997）, TNF-α （1.18 ± 0.22 ng/L vs. 1.51 ± 0.21 ng/L, t=-7.476）, IL-1β （25.14 ± 6.17 ng/ml vs. 40.26 ± 6.07 ng/ml, t=-12.038）, IL-6 （93.85 ± 23.02 μg/L vs. 110.63 ± 24.07 μg/L, t=-3.473） and TXB2 （299.36 ± 52.16 pg/ml vs. 429.17 ± 53.62 pg/ml, t=-11.961） of research group were significantly lower than those of the control group （P〈0.05）. Both groups had adverse events during the treatment. Conclusions Acupuncture combined with Jintiange capsule could effectively improve the clinical symptoms, release pain and decrease the serum inflammatory factors of patients with LDH.
出处
《国际中医中药杂志》
2018年第1期26-29,共4页
International Journal of Traditional Chinese Medicine
关键词
椎间盘移位
针刺镇痛
金天格胶囊
临床研究
Intervertebral disc displacement
Acupuncture analgesia
Jintiange capsule
Clinical study
