摘要
本文报告用重组hGH治疗特发性生长激素缺乏侏儒第二年的疗效。剂量和方法同第一年,身高生长速率由1.9±1.0cm/年增加至9.2±1.2cm/年,比第一年治疗生长速率10.7±0.5cm/年为低(P<0.05)。结果显示,剂量以每周0.7IU/kg分7次皮下注射比每周0.5IU/kg分3次肌肉注射疗效更好。9例患者用药后8例T_4降低,无临床甲状腺功能低下症状,2例有抗hGH抗体,但不妨碍生长,无其他副作用。
Nine previously treated idiopathic growth hormone deficiency children were treated again with recombinant hGH for one year. The dosage and route of administration were the same as those in the previous treatment. The height velocity increased from 1.5 ± 1.0cm/year (mean±SD) to 9.2 ± 1.2cm/year. Compared with the height velocity (10.7 ± 0.5cm/a) in the first year treatment, it decreased in the second year (P<0.05). The results also showed that the effect was better with a dosage of 0.7 IU/kg/wk divided into 7 s.c. doses than with 0.5 IU/kg/wk divided into 3 i.m. doses. Eight of the 9 cases had low serum T4 after treatment, but no symptoms of hypothyrcidism were seen. Anti-hGH antibody was observed in 2 cases, though it did not affect the height velocity. No other side effects were noticed during treatment.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1991年第6期443-446,共4页
Acta Academiae Medicinae Sinicae
关键词
侏儒
生长激素
重组
idiopathic growth hormone deficiency recombinant human growth hormone pituitary dwarfism
