摘要
目的：观察和分析益肾补脾方干预慢性肾脏病3期的疗效及对肾功能、TGF-β1水平的影响,旨在提高疗效。方法：126例慢性肾脏病3期患者,采用随机数字表法,按照1∶1比例将其随机分为观察组和对照组（每组63例）,两组患者均采用同样的健康宣教和基础治疗干预,观察组加用益肾补脾方。比较两组患者临床综合疗效、肾功能和TGF-β1水平。结果：观察组临床综合疗效显效率42.86%、总有效率92.06%,高于对照组的15.87%、68.25%,差异有统计学差异（P〈0.05）。治疗后,尿素氮、血肌酐、尿酸、24 h尿蛋白和TGF-β1水平低于对照组,内生肌酐清除率和肾小球滤过率高于对照组,差异有统计学意义（P〈0.05）。组间治疗前后,24 h尿蛋白和TGF-β1水平差值,观察组优于对照组,差异有统计学意义（P〈0.05）。结论：益肾补脾方干预慢性肾脏病3期疗效确切,能显著保护肾功能、调节TGF-β1水平,具有标本兼治的效果,值得推广。
Objective： To observe and analyze the effect of Yishen Bupi Recipe on renal function and TGF-β1 level in patients with chronic kidney disease（ CRRD） and improve the curative effect. Methods： From February 2014 to August 2016,126 patients with CKD 3 were randomly selected and randomly divided into the observation group and the control group（63 cases in each group） according to the ratio of 1 ∶ 1. The patients were treated with the same health education and basic treatment. The observation group was treated with Yishen Bupi Recipe. The clinical efficacy,renal function and TGF-β1 levels were compared between the two groups. Results：The total effective rate was 92. 06%,which was higher than that of the control group（15. 87%,68. 25%）. The difference was statistically significant（ P 〈 0. 05）. After treatment,the levels of creatinine,uric acid,24 h urinary protein and TGF-β1 were lower than those of the control group. The creatinine clearance rate and glomerular filtration rate were significantly higher than those of the control group（P 〈 0. 05）. The difference of 24-hour urine protein and TGF-β1 level between the two groups was statistically significant（ P 〈 0. 05）,which was better than that of the control group. Conclusion： Yishen Bupi Recipe has obvious curative effect on renal function and regulating the level of TGF-β1 in treating chronic kidney disease. It has the effect of treating both the symptoms and the causes.
出处
《中华中医药学刊》
CAS
北大核心
2018年第1期238-241,共4页
Chinese Archives of Traditional Chinese Medicine
基金
河南省科技厅一般项目(20139802301k)
