摘要
目的:探讨急性脑梗死患者同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)及凝血功能指标水平变化及意义。方法:110例急性脑梗死患者设为观察组,依据急性脑梗死症状发生至96h神经功能缺失症状是否有进行性加重,观察组又可分为进展组(n=65例)和非进展组(n=45例),同期另选取健康体检者110例作为对照组。比较各组间血脂代谢、Hcy、hs-CRP及凝血功能指标水平。结果:单因素方差分析结果表明,各组间血脂代谢、Hcy、hs-CRP及凝血功能指标水平比较差异均具有统计学意义(P<0.05)。与对照组中指标水平比较,观察组TG、TC、LDL、Hcy、hs-CRP、D-dime,FIB水平均显著升高,HDL水平显著降低,差异有统计学意义(P<0.05);进展组TG、TC、LDL、Hcy、hs-CRP、D-dime,FIB水平均显著高于非进展组,HDL水平显著低于非进展组,差异有统计学意义(P<0.05);相关性分析结果表明,急性脑梗死病情程度与TG、TC、LDL、Hcy、hs-CRP、D-dime,FIB水平呈显著正相关性(P<0.05),与HDL水平呈显著负相关性(P<0.05)。结论:急性脑梗死患者存在血脂代谢及凝血功能异常,Hcy及hs-CRP水平显著升高,各指标检测对急性脑梗死病情程度评估具有重要意义。
Objective:To explore the changes and significance of homocysteine(Hcy),high sensitivity C reactive protein(hs-CRP)and coagulation function indexes in patients with acute cerebral infarction.Methods:A total of 110 patients with acute cerebral infarction were selected as the observation group,According to the symptoms of acute cerebral infarction to 96 h,whether the symptoms of neurological deficit were aggravated,the patients in the observation group could be divided into the progressive group(n=65 case)and the non progressive group(n=45 case),and 110 cases of healthy physical examination were selected as control group at the same time.The levels of blood lipid metabolism,Hcy,hs-CRP and blood coagulation function were compared in each group.Results:Single factor analysis showed that there was a statistically significant difference in blood lipid metabolism,Hcy,hs-CRP and coagulation function between groups(P<0.05).Compared with the index level in the control group,the levels of TG,TC,LDL,Hcy,hs-CRP,D-dime and FIB in the observation group were significantly higher than those in the control group,and the HDL level was significantly decreased,the difference was statistically significant(P<0.05).The levels of TG,TC,LDL,Hcy,hs-CRP,D-dime and FIB in the progression group were significantly higher than those in the non progressive group,HDL level was significantly lower than that in the non progressive group,with significant difference(P<0.05).Correlation analysis showed that the severity of acute cerebral infarction was positively correlated with the levels of TG,TC,LDL,Hcy,hs-CRP,D-dime and FIB(r=0.536,0.780,0.697,0.390,0.636,0.429,0.482,P<0.05),and negatively correlated with HDL level(r=-0.241,P<0.05).Conclusion:There are abnormalities of blood lipid metabolism and coagulation function in patients with acute cerebral infarction,and the levels of Hcy and hs-CRP increase significantly.Detection of all indexes is of great significance for evaluating the severity of acute cerebral infarction.
出处
《海南医学院学报》
CAS
2018年第1期121-124,共4页
Journal of Hainan Medical University
基金
新疆维吾尔自治区自然科学基金(2016E02C127)~~
