摘要
目的:探讨腹腔镜子宫肌瘤剔除术对患者炎症反应、免疫功能、应激激素及卵巢功能的影响。方法:选取符合研究筛选标准的82例子宫肌瘤患者作为研究对象,依据随机数据表法平均分为对照组(n=41)和观察组(n=41),对照组患者接受传统开腹子宫肌瘤剔除术治疗,观察组患者给予腹腔镜子宫肌瘤剔除术治疗。比较两组治疗前后(手术前及手术1d后)炎症反应、免疫功能、应激激素及卵巢功能等指标水平。结果:经比较可知,治疗前组间TNF-α、CRP、CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、COR、NE、LH、FSH、E2水平差异无统计学意义(P>0.05);治疗后,两组TNF-α、CRP、CD8^+、COR、NE、LH、FSH水平均显著升高,且治疗后对照组水平显著高于观察组,差异有统计学意义(P<0.05);观察组CD3^+、CD4^+、CD4^+/CD8^+、E2水平均显著高于对照组,差异有统计学意义(P<0.05)。结论:腹腔镜子宫肌瘤剔除术可有效减轻患者手术产生的炎症反应及应激反应,对机体免疫功能及卵巢功能的影响较小,更有利于术后康复。
Objective:To investigate the effect of laparoscopic myomectomy on inflammatory reaction,immune function,stress hormones and ovarian function.Methods:According to the screening criteria a total of 82 patients with hysteromyoma were selected as the objects of study,according to the random data table,the patients were divided into the control group(n=41)and the observation group(n=41);The patients in the control group received traditional laparotomy myomectomy,and the observation group patients received laparoscopic myomectomy.The inflammatory reaction,immune function,stress hormone and ovarian function levels were compared between the two groups before and after treatment(before operation and after operation 1 d).Results:After comparison,before treatment the difference of TNF-α,CRP,CD3^+,CD4^+,CD8^+,CD4^+/CD8^+,COR,NE,LH,FSH and E2 levels between the groups was not statistically significant(P>0.05);After treatment,the two groups of TNF-α,CRP,CD8^+,COR,NE,LH and FSH levels were significantly increased,and after treatment the levels in the control group were significantly higher than the observation group,the difference was statistically significant(P<0.05);The levels of CD3^+,CD4^+,CD4^+/CD8^+and E2 in the observation group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).Conclusions:Laparoscopic myomectomy can effectively reduce the inflammatory reaction and stress reaction,and have a less influence on the immune function and ovarian function,which is more conducive to postoperative rehabilitation.
出处
《海南医学院学报》
CAS
2018年第1期37-40,共4页
Journal of Hainan Medical University
基金
四川省卫生厅科研课题(150241)~~
