摘要
目的 ：探讨独活寄生汤联合强的松治疗风湿性多肌痛的疗效。方法 ：选取2014年2月—2016年2月医院诊治的风湿性多肌痛患者80例为研究对象,根据随机数字表法分为观察组和对照组,各40例。对照组采用强的松治疗。观察组在对照组基础上应用独活寄生汤治疗,比较两组患者治疗效果,治疗前后PMR-AS及ESR水平的变化,治疗4周、8周及12周强的松用量及不良反应。结果 ：观察组临床缓解、显效例数多于对照组,有效及无效例数少于对照组,经秩和检验,两组疗效具有统计学差异（μ=8.285,P〈0.05）。治疗后,两组PMR-AS[（37.6±10.4）分vs（7.9±2.1）分、（37.9±11.5）分、（14.6±4.6）分]及ESR[（71.3±21.4）mm/h vs（19.8±5.4）mm/h、（72.9±24.6）mm/h vs（38.7±11.8）mm/h]均较治疗前显著降低,差异有统计学意义（P〈0.05）。且组间比较,观察组治疗改善较对照组更显著[（7.9±2.1）分vs（14.6±4.6）分、（19.8±5.4）mm/h vs（38.7±11.8）mm/h],差异有统计学意义（t=8.379,9.211,P〈0.05）。用药8周及12周,两组强的松用量均呈降低趋势,组间比较,观察组8周及12周强的松用量均显著低于对照组[（5.6±1.4）g/d vs（12.3±3.8）g/d、（1.8±0.5）g/d vs（6.5±2.1）g/d],差异有统计学意义（t=8.379,9.211,P〈0.05）。观察组不良反应发生率为15.0%,显著低于对照组的35.0%,差异有统计学意义（χ~2=4.267,P〈0.05）。结论 ：独活寄生汤联合强的松治疗风湿性多肌痛能够显著的提高疗效,降低强的松用药剂量,降低不良反应。
Objective ：To investigate the effect of Duhuo Jisheng Decoction combined with prednisone in the treatment of polymyalgia rheumatica. Methods ：A total of 80 patients with rheumatic myalgia diagnosed in the hospital from February 2014 to February 2016 were selected as the subjects,according to the random number table method,they were divided into observation group and control group,40 cases in each group. The control group was treated with prednisone. The observation group were treated with Duhuo JishengDecoction on the basis of the control group,the treatment period was 12 weeks. The treatment effects,the changes of PMR-AS and ESR levels before and after treatment,the dosage of 4 W,8 W and 12 W,prednisone and adverse reactions were compared between the two groups. Results ：The clinical remission and effective cases in the observation group were more than those in the control group,the number of effective and ineffective cases was less than that of the control group,and the rank sum test,The curative effect of the two groups had statistical difference（μ=8.285,P〈0.05）. After treatment,the two groups of PMR-AS[（37.6±10.4）points vs（7.9±2.1）points、（37.9±11.5）points vs（14.6±4.6）points]and ESR[（71.3±21.4）mm/h vs（19.8±5.4）mm/h、（72.9±24.6）mm/h vs（38.7±11.8）mm/h] were significantly lower than before treatment,the difference was statistically significant（P〈0.05）. Compared with the control group,the improvement of the observation group was more significant[（7.9±2.1）points vs（14.6±4.6）points、（19.8±5.4）mm/h vs（38.7±11.8）mm/h],the difference was statistically significant（t=8.379,9.211,P〈0.05）. The dosage of prednisone in the two groups decreased with the use of 8 W and 12 W,and compared between the two groups,the dosage of prednisone in the observation group,8 W and 12 W were significantly lower than that in the control group[（5.6±1.4）g/d vs（12.3±3.8）g/d、（1.8±0.5）g/d vs（6.5±2.1）g/d],the difference was statistically significant（t=8.379,9.211,P〈0.05）. The incidence of adverse reactions was 15% in the observation group,significantly lower than 35% in the control group,the difference was statistically significant（χ~2=4.267,P〈0.05）. Conclusion ：Duhuo Jisheng Decoction combined with prednisone in the treatment of polymyalgia rheumatica can improve the efficacy significantly,Reduce the dosage of prednisone and reduce the adverse reaction.
出处
《辽宁中医药大学学报》
CAS
2018年第1期187-189,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
上海中医药大学资助项目(2016YSN72)
关键词
独活寄生汤
强的松
风湿性多肌痛
风湿
Duhuo Jisheng Decoction
prednisone
rheumatic polymyalgia
rheumatica
