摘要
对10例视网膜母细胞瘤(retinoblastoma,Rb)患儿染色体作高分辨G带分析,发现3例有13q14.2缺失;3例患儿的父亲均有类似缺失,但是嵌合缺失,患儿父亲异常细胞所占比值分别为10％、14％和21％。本研究结果提示,视网膜母细胞瘤患者染色体13q 14缺失的发现率有上升趋势,且染色体13q 14缺失均来源于父亲。
We analyzed the G-banded high-resolution chromosomes of 10 patients with retinoblastoma and found 3 cases with 13q14.2 deletion. Their fathers showed similar but mosaic deletions. The proportions of abnormal cells were 10%, 14% and 21% in the fathers of cases 4, 8 and 10, respectively. The incidence and extent of deletion are discussed. The results suggest that the incidence of 13q14 deletion in retinoblastoma patients rose.The findings suggest that the three 13q14 deletion carriers who did not develop retinoblastoma transmitted the deletion to their children.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1991年第3期157-160,共4页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金
