摘要
目的探讨25-OH维生素D(25-OH VD)水平与自身免疫性肝炎(AIH)的相关性。方法选择新乡医学院第一附属医院感染科住院的150例AIH患者作为观察组,体检结果正常的健康人70例作为对照组。取清晨空腹静脉血,采用酶联免疫吸附法检测2组受试者的血清25-OH VD水平。收集研究对象临床资料并分析影响AIH患者血清25-OH VD水平的因素。结果观察组患者的维生素D缺乏患病率(84.67%)显著高于对照组受试者(34.29%)(χ~2=56.28,P<0.05)。治疗前观察组患者的血清25-OH VD水平显著低于对照组受试者(P<0.05)。观察组患者中,治疗前≥60岁组患者的血清25-OH VD水平显著低于30~49岁组和50~59岁组患者(P<0.05);50~59岁组患者血清25-OH VD水平显著低于30~49岁组患者(P<0.05)。治疗后观察组患者的血清25-OH VD水平显著高于治疗前(P<0.05);30~49岁组、50~59岁组和≥60岁组患者治疗后血清25-OH VD水平均显著高于治疗前水平(P<0.05)。治疗后观察组中≥60岁组患者的血清25-OH VD水平显著低于30~49岁组和50~59岁组患者(P<0.05);50~59岁组患者的血清25-OH VD水平显著低于30~49岁组患者(P<0.05)。观察组患者中维生素D缺乏者的年龄、病程、体质量指数及血清Ca2+、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、r-谷氨酰转肽酶(r-GT)和免疫球蛋白G(Ig G)、Ig M水平均高于维生素D不缺乏患者,血清白蛋白水平低于维生素D不缺乏患者(P<0.05);性别及甲状旁腺激素、总胆红素、碱性磷酸酶水平在维生素D缺乏和不缺乏患者间比较差异无统计学意义(P>0.05)。AST、ALT、r-GT水平是25-OH VD的独立影响因素(P<0.05)。结论 AIH患者的血清25-OH VD水平较低,ALT、AST及r-GT是影响AIH患者血清25-OH VD水平的重要因素。
Objective To investigate the correlation between autoimmune hepatitis（ AIH） and 25-hydroxyvitamin D（ 25-OH VD） level. Methods A total of 150 patients with AIH in the First Affiliated Hospital of Xinxiang Medical University were selected as the observation group,and 70 healthy people with were selected as the control group. The fasting venous blood was taken from the subjects in the two groups. The level of serum 25-OH VD were detected by enzyme-linked immunosorbent assay. The clinical data of the subjects were collected and the factors influencing the serum 25-OH and VD level in AIH patients were analyzed. Results The rate of vitamin D deficiency in the observation group was significantly higher than that in the control group（ 84. 67% vs 34. 29%; χ~2= 56. 28,P 0. 05）. The level of 25-OH VD in the observation group was significantly lower than that in the control group before treatment（ P 0. 05）. The level of 25-OH VD in the patients with more than60 years old was significantly lower than that in the patients with 30-49 and 50-59 years old in the observation group before treatment（ P 0. 05）. The level of 25-OH VD in the patients with 50-59 years old was significantly lower than that in the patients with 30-49 years old before treatment（ P 0. 05）. The level of 25-OH VD after treatment was significantly higher than that before treatment in the observation group（ P 0. 05）. The level of 25-OH VD after treatment was significantly higher than that before treatment in the patients with 30-49,50-59 and more than 60 years old（ P 0. 05）. The level of 25-OH VD in the patients with more than 60 years old was significantly lower than that in the patients with 30-49 and 50-59 years old in the observation group after treatment（ P 0. 05）. The level of 25-OH VD in the patients with 50-59 years old was significantly lower than that in the patients with 30-49 years old after treatment（ P 0. 05）. The age,course of disease,body mass index,and the levels of serum alanine transarninase（ ALT）,aspartate aminotransferase（ AST）,r-glutamyl transpeptidase（ rGT）,immunoglobulin G（ Ig G）,Ig M in the patients with vitamin D deficiency were significantly higher than those in the patients without vitamin D deficiency in the observation group（ P 0. 05）; but the level of seralbumin in the patients with vitamin D deficiency was significantly lower than that in the patients without vitamin D deficiency（ P 0. 05）. There was no significant difference in the age and the levels of serum parathyroid hormone,total bilirubin,alkaline phosphatase between the patients with vitamin D deficiency and the patients without vitamin D deficiency（ P 0. 05）. The levels of serum AST,ALT and r-GT were the independent influencing factors for 25-OH VD（ P 0. 05）. Conclusion The level of serum 25-OH VD is lower in the patients with AIH,and ALT,AST and r-GT were important factors affecting serum 25-OH VD level in patients with AIH.
出处
《新乡医学院学报》
CAS
2017年第12期1080-1084,共5页
Journal of Xinxiang Medical University
基金
河南省教育厅自然科学研究计划项目(编号:2008B320009)
