摘要
目的 研究热休克蛋白 70 (HSP70 )在食道鳞状细胞癌中的表达与意义 .方法 采用鼠抗人 HSP70单克隆抗体及免疫组织化学 SABC法 .结果 在 60例食道鳞状细胞癌中 ,HSP70表达 46例 (76.7% ) .HSP70在食道鳞状细胞癌 级中表达强于在食道鳞状细胞癌 级中的表达 (P<0 .0 5) .结论 HSP70在大部分食道鳞状细胞癌中有不同程度表达 ,HSP70可能参与食道鳞状细胞癌的凋亡调变 ;
AIM To study the expression and significence of HSP70 in esophagus squamous cell carcinomas. METHODS Streptavidin Biotin peroxidase Complex (SABC) methods, monoclonal antibody against HSP70 were employed. RESULTS HSP70 immunoreactivity was detected in 46 out of 60 cases of esophagus squamous cell carcinoma. The expression of HSP70 in esophagus squamous cell carcinoma significant difference was not found between the different grades in proper order of esophagus squamous cell carcinoma ( P >0.05), and in 20 low grade (WHO GradeⅠ) esophagus squamous cell carcinomas was higher than that in 20 cases high grade (WHO GradeⅢ )esophagus squamous cell carcinomas ( P <0.05). CONCLUSION HSP70 are differently expressed in most of esophagus squamous cell carcinomas and that HSP70 may take part in the modulation of apoptosis in esophagus squamous cell carcinomas.
出处
《第四军医大学学报》
北大核心
2002年第16期1505-1506,共2页
Journal of the Fourth Military Medical University
