摘要
目的 观察二氢石蒜碱 (dihydrolycorine ,DL)对家兔脑血管的选择性作用。方法 采用家兔离体基底动脉(BA)、胸主动脉 (TA)及心室乳头肌 (PM)标本 ,记录药物对其张力的影响。结果 DL使BA静息张力升高 ,尼莫地平(Nim)则使其降低 ,对TA无影响。NA、KCl所致BA及TA收缩 ,DL使之呈剂量依赖性松弛 ,其IC50 值 :对BA分别为(6 6 9± 3 12 )× 10 -4、(3 4 1± 1 5 2 )× 10 -3 mol·L-1;对TA分别为 (1 4 9± 0 5 9)× 10 -3 、(2 91± 0 99)× 10 -3 mol·L-1。拮抗NA所致基底动脉收缩作用强于KCl。Nim对KCl所致收缩的抑制强于对NA。DL或Nim对电刺激诱发PM的收缩均有剂量依赖性抑制作用 ,DL对电刺激诱发PM收缩的IC50 值高于NA所致BA收缩IC50 值。结论 DL对BA有明显的选择性作用 ,在BA可能存在使该血管平滑肌收缩的α1受体亚型和使之舒张的 β受体。DL作用可能与对这些受体的阻断作用相关。
AIM To observe the selective effects of dihydrolycorine (DL) on isolated cerebral blood vessel of rabbit. MOTHEDS The isolated basilar artery(BA) and thoracic aorta(TA) and papillary muscles(PM) preparations were used to record change of tension induced by drugs. RESULTS Resting tension of BA was raised by DL and reduced by Nim. But both drugs had little effect in TA. DL produced a contraction dependent relaxation in noradrenaline (NA 100 μmol·L -1 ) or KCl (60 mmol·L -1 ) contracted BA and TA rings. The relaxative effect of DL was more potent in BA rings contracted by NA than that by KCl. The IC 50 values ware (6 69±3 12)×10 -4 and (3 41±1 52)×10 -3 mol·L -1 respectively. In the TA, DL inhibited contraction induced by NA,the IC 50 value was less than that in the BA. DL or Nim produced a concentration dependent inhibition of the contraction respones induced by electrical stimulation in PM. IC 50 value of DL inhibited contraction of the PM induced by electrical stimulation was significantly greater than that by NA in BA rings ( P< 0 01). CONCLUSION These data demonstrate that the DL had selected effects on BA. It may be related to antagonistic α 1 subtype and β receptor. The results suggest that DL may help in improving cerebral blood flow in cerebral ischemic area.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2002年第4期409-411,共3页
Chinese Pharmacological Bulletin
基金
湖北省自然科学基金资助课题
No 2 0 0J166
