摘要
血小板衍生生长因子(platelet-derived growth factor,PDGF)是一类重要的促血管生成因子,是多种细胞的促有丝分裂剂和趋化因子,血小板衍生生长因子受体(platelet-derived growth factor receptor,PDGFR)是络氨酸蛋白激酶家族成员,能促进细胞的趋化增殖,PDGF和PDGFR在肿瘤发生发展中起着重要作用,以PDGF/PDGFR为靶点作为肿瘤靶向治疗的研究也有了较大的进展。
Platelet-derived growth factor（PDGF） is a kind of angiogenic factor, is a variety of cell mitogenic agents and chemokines, platelet-derived growth factor receptor（PDGFR） is a member of the lysine protein kinase, which can promote the chemotaxis of cells. PDGF and PDGFR play an important role in the development of tumor. The study of PDGF/PDGFR as a target for tumor therapy has also made great progress. In this paper, review the progress of PDGF-BB/PDGFR-β in the development of tumor and the progress of tumor targeting therapy.
出处
《临床与病理杂志》
2017年第11期2457-2462,共6页
Journal of Clinical and Pathological Research
基金
国家自然科学基金(81360401
81660448)~~
