摘要
微小RNA（miRNA）-184是一个长度为22个核苷酸的内源性非编码蛋白的单链小分子RNA，且在生物进化过程中极其保守，为重要的转录后基因表达调控因子，其功能涉及多种组织、器官的生长发育、分化、功能维持和凋亡等生物学过程。有关miRNA．184在眼部的生理作用及其与眼部疾病关系的研究日益受到重视。研究结果表明miRNA-184在小鼠角膜和晶状体中呈特异性高表达；miRNA-184在眼部的新生血管生成、圆锥角膜、眼前节发育不良综合征、角膜鳞状细胞癌、白内障、老年性黄斑变性等病变的发生与发展中发挥重要的调控作用。本文就miRNA-184分子的基因结构、基因表达与调控、生物学功能以及其与眼部疾病的相关性研究进展进行综述，以期为临床工作提供参考。
microRNA-184 （miR-184） is a small, non-coding, endogenic RNA molecule of 22 nueleotides in length. It is a highly conserved sequence throughout many different species. Multiple studies have demonstrated that miR-184 is an important factor in regulating gene expression at the post- transcriptional level, miR-184 plays vital roles in many biological processes, including development and differentiation in many tissues and organs. Meanwhile, the research on the physiological and pathological role of miR-184 in eyes draws more and more attention lately. Recent research indicates that miR-184 is highly expressed in the cornea and lens of mice. miR-184 plays crucial regulatory roles in several ocular diseases, such as neovascularization, keratoeonus, endothelial dystrophy-iris hypoplasia-eongenital cataract- stromal thinning syndrome, corneal squamous cell carcinoma, age-related maeular degeneration and cataract. Here we summarize and discuss the recent findings of miR-184 in its gene structure, gene expression and regulation, biological function and its relevance with ocular diseases.
出处
《中华眼科杂志》
CSCD
北大核心
2017年第12期950-955,共6页
Chinese Journal of Ophthalmology
