摘要
甘草是一种药食同源的中药,其性味甘,平.归心、肺、脾、胃经,具有抗炎、抗氧化、抗病毒、抗溃疡、解痉挛、抗过敏、抗糖尿病、抗抑郁以及保护肝脏等药理作用.甘草作为临床常见的降低毒性和调和药性之药,在与有毒中药配伍的过程中主要起"减毒"的作用,但其具有两面性,即增强毒性又解毒或增强疗效,因此,甘草被称为"双向"草药.文章通过甘草与有毒中药配伍后,对物质基础变化、毒副作用、药效、药代动力学及其代谢组学方面的影响,研究增毒与减毒作用机理.
Licorice is a kind of medicinal and edible Traditional Chinese Medicine,sweet and flat in taste,at-tributive to heart,lung,spleen and kidney channels.It has the pharmacological action of anti-in-flammatory,antioxidant,antiviral,anti-ulcer,lifting spasm anti-anaphylaxis,anti-diabetic,an-ti-depression and protecting live etc.Licorice reduces toxicity mainly in the process of compatibili-ty with toxic Traditional Chinese Medicine as the common medicine of reducing toxicity and bal-ancing drug properties.It has dual characters,that is,it not only enhances the toxicity but also re-duces the toxicity or improve drug efficacy.Thus,Licorice is called bidirectional herb.The articlestudys the enhancing and reducing toxicity mechanism of action on compatibility of toxic Tradition-al Chinese Medicine with licorice by material basis variation,toxic and side effect,pharmacody-namics,pharmacokinetics and metabonmics.
出处
《通化师范学院学报》
2018年第2期12-17,共6页
Journal of Tonghua Normal University
基金
国家自然科学基金项目(2016091114)
关键词
有毒中药
甘草
配伍
增毒与减毒
作用机理
toxic Traditional Chinese Medicine
licorice
compatibility
enhancing and reducing toxicity
mechanism of action
