摘要
目的:探讨干扰素α-2b联合肠溶阿司匹林治疗真性红细胞增多症的疗效及对凝血功能的影响。方法:将86例真性红细胞增多症患者按随机数字表法分为两组,每组43例,对照组给阿司匹林治疗,观察组在对照组基础上给予干扰素α-2b治疗,比较两组血液学指标、疗效及不良反应。结果:治疗5个月后,观察组血小板计数(PLT)、白细胞(WBC)、红细胞压积(HCT)、血红蛋白(Hb)、红细胞(RBC)水平明显低于对照组(P<0.05);观察组完全缓解率明显高于对照组,部分缓解及复发率均较低(P<0.05);治疗期间,两组均未出现明显肝、肾功能异常情况。结论:干扰素α-2b联合肠溶阿司匹林治疗可改善真性红细胞增多症患者凝血功能,提高治疗效果,且安全性较好。
Objective:To investigate the effect of interferon α-2b combined with enteric-coated aspirin in the treatment of polycythemia vera and its effect on coagulation.Methods:86 cases of patients with polycythemia vera were treated they were divided into two groups according to the random number table method.The control group received aspirin treatment,and the observation group was treated with interferon α-2b on the basis of the control group.The hematological parameters,curative effect and adverse reaction were compared between the two groups.Results:After treatment for 5 months,the levels of platelet count(PLT),white blood cell(WBC),hematocrit(HCT),hemoglobin(Hb)and erythrocyte(RBC)in the observation group were significantly lower than those in the control group(P<0.05);The complete remission rate of the observation group was significantly higher than that of the control group.The partial remission and recurrence rate were all lower(P<0.05).During the treatment period,there was no abnormal liver and renal function in the two groups.Conclusion:Interferon α-2b combined with enteric-coated aspirin can improve the coagulation function of patients with polycythemia vera,improve the therapeutic effect,and the safety is good,it is worthy of positive application promotion.
出处
《陕西医学杂志》
CAS
2018年第1期61-63,共3页
Shaanxi Medical Journal
基金
河北省张家口市科技局课题(1321053D)
