摘要
目的:通过对原发性高血压患者及其不同分级之间风疹病毒IgM抗体阳性率进行分析,探讨风疹病毒IgM抗体与原发性高血压发生、发展之间的关系。方法:选取2013年3月-2015年2月笔者所在医院收治的原发性高血压患者174例(1级29例,2级62例,3级83例)为原发性高血压组,选取同期的健康体检者111例为正常对照组,人群个体间无血缘关系。采用酶联免疫法对上述人群风疹病毒IgM抗体进行检测,所有阳性标本均经复检确认。试验数据用SPSS 22.0软件进行统计分析。结果:原发性高血压组风疹病毒IgM抗体阳性率为6.90%(12/174),对照组0.90%(1/111),比较差异有统计学意义(χ~2=5.596,P=0.018),风疹病毒IgM抗体阳性是原发性高血压的危险因素,与疾病正相关(P=0.018,OR=8.148)。不同分级高血压患者风疹病毒IgM抗体阳性率分别为1级6.90%(2/29)、2级4.84%(3/62)、3级8.43%(7/83),三者比较差异无统计学意义(Fisher’s精确概率法χ~2=0.741,P=0.725)。高血压患者ALT、AST、BUN、GLU、LDL明显高于对照组,比较差异均有统计学意义(P<0.05);而TC、HDL、APOA、APOB明显较正常对照组低,比较差异均有统计学意义(P<0.05)。经调整其他变量影响后的二分类Logistic回归分析,发现风疹病毒IgM抗体阳性并非原发性高血压的主要危险因素(P=0.625)。结论:风疹病毒感染能够增加原发性高血压的患病风险,但并非主要影响因素。
Objective：To explore the association of rubella virus IgM antibody（RV-IgM） and the occurrence and development of essential hypertension by analyzing the positive rate of rubella virus IgM antibody among patients with essential hypertension and their different grades.Method：From March 2013 to February 2015,174 essential hypertension patients（29 cases in grade 1,62 cases in grade 2,83 cases in grade 3） as the essential hypertension group and 111 normal healthy subjects as the healthy control group were recruited in the study,all the subjects were unrelated.The serum RV-IgM antibodies were detected by means of Enzyme-linked immunosorbent assay（ELISA）.In order to verify the positive samples,they were all retested.Calculations and statistical analyses were performed using the SPSS for Windows software（version 22.0）.Result： The frequency of serum RV-IgM antibody was 6.90%（12/174） in the essential hypertension group,and 0.90%（1/111） in the healthy control group,the difference was statistically significant（ χ^2=5.596,P=0.018）,the positive RV-IgM was considered to be a risk factor for essential hypertension（P=0.018,OR=8.148）.The prevalence of RV-IgM antibody was 6.90%（2/29） in grade 1 hypertensions,4.84%（3/62） in grade 2 and 8.43%（7/83） in grade 3,respectively,there was no significant difference among these three grades（ χ^2-Fisher’s=0.741,P=0.725）.Besides,ALT,AST,BUN,GLU,LDL in the essential hypertension group were significantly higher than those in the healthy control group,the differences were statistically significant（P〈0.05）,but TC,HDL,APOA,APOB in the essential hypertension group were significant lower than those in the healthy control group,the differences were statistically significant（P〈0.05）.Logistic regression analysis showed that rubella virus IgM antibody was not the main risk factor of essential hypertension after adjusting for other variables（P=0.625）.Conclusion： Rubella virus infection can increase the risk of essential hypertension,but it is not the major factor.
出处
《中外医学研究》
2017年第35期1-3,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
江苏省连云港市卫生局项目(项目编号:1321)
