摘要
胶质瘤干细胞(GSCs)具有自我更新、形成神经球、表达干细胞标志物、多向分化、较高侵袭力、放化疗抵抗等特性,这些特性被认为是胶质瘤复发的主要因素.GSCs作为胶质瘤治疗的重要靶标,主要是通过抑制维持GSC干性所需的细胞表面标志物的表达以及阻断相关特异性分子通路,从而减少GSCs增殖,促进其分化,降低其致瘤性来杀伤GSCs.近年来,GSCs与其所处的血管周围/增生性微环境以及缺氧/周围坏死性微环境的相互作用逐渐被关注.研究发现血管周围微环境及坏死周围缺氧区域中,存在一些分子和细胞,通过分子信号转导机制,增强GSCs的干细胞样特性,促进了这些细胞的侵袭和转移,使GSCs在治疗中幸存.因此深入了解这一机制,破坏这些微环境,寻找新的靶点,可以为胶质瘤的治疗开辟一条新的路径.
Glioma stem cells （GSCs） have the characteristics of self-renewal, the formation of neurospheres, the expression of stem cell markers, multi-directional differentiation, higher invasion, radiotherapy and chemotherapy resistance, and these characteristics are considered to be the main cause of glioma recurrence. As a relevant target for glioblastoma therapy, the elimination of GSCs is crucial in treating glioblastoma. The strategy to target GSCs therapeutically is mainly focused on the direct ablation of GSCs by targeting cell surface markers and specific pathways that are required for maintaining GSCs stenmess. However, it has been increasingly acknowledged that another way to specifically target GSCs is to alter ＇.he ability of GSCs to interact with their microen- vironments. GSCs exist in specific niches （perivascular/proliferatire niche and hypoxic/perinecrotic niche） that play a role in enhancing the stem-like features of GSCs, promoting invasion and metastasis of GSCs, and even making GSCs survive. Recognition of these mechanisms has opened doors for targeting GSCs.
作者
任东妮
王震
刘楠
涂艳阳
REN Dong-Ni;WANG Zhen;LIU Nan;TU Yan-Yang(Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi＇an 710038, China;Department of Biology, Xi＇an Jiaotong University, Xi＇an 710049, China)
出处
《转化医学电子杂志》
2017年第12期57-63,共7页
E-Journal of Translational Medicine
基金
国家自然科学基金(81572983
81272419)
陕西省社会发展科技攻关项目(2015SF027)
唐都医院创新发展基金资助项目(2016JCYJ013)
