摘要
对尿毒症患者血小板数目,粘附率和膜糖蛋白Ib含量进行了测定。结果表明:尿毒症组血小板数目和血小板粘附率均显著低于对照组(P<0.0I),血小板膜糖蛋白Ib含量测定也显著低于对照组(P<0.01),而且尿毒症组血小板粘附率与膜糖蛋白Ib之间呈现有意义的正相关(γ=0.46 P<0.01)。实验结果提示,尿毒症患者出血倾向的发生机制与血小板量和其他质的改变有密切关系,尤其血小板膜糖蛋白Ib含量的变化可能是主要原因之一。本实验见到了膜糖蛋白Ib与血小板粘附功能关系密切,血液中储积的毒性代谢产物可能是导致血小板膜损害和功能障碍的主要原因。
In this study, platelet count, adhesion rate and membrane glycoproteinIb concentration were determined in uremic patients, The results showed thatplatelet count, adhesion rate and membrane glycoprotein Ib concentration inuremia group were decreased significantly compared with the control group(P<0.01) and there was significant positive correlation between the plateletadhesion rate and membrane glycoprotein Ib concentration in uremia group(γ=0.46, P<0.01). Our data indicate: the mechanism of bleeding tendencyin uremic patients was closely related to the quantitative and qualitativechange of platetet, furthermore, the platelet membrane glycoprotein Ib concen-tration change may be one of the important causative factors for the bleeding.It has been noted that close relationship exists between platelet adhesionfunction and membrane glycoprotein Ib concentration. The toxic metabolicproducts accumulated in blood are supposed to be the main reason for plateletmembranous dysfunction and damage.
出处
《中国医科大学学报》
CAS
CSCD
1991年第4期292-295,共4页
Journal of China Medical University
关键词
尿毒症
血小板
粘附率
膜糖蛋白
platelet adhesion rate
platele membrane glycoprotein Ib
uremia
