摘要
目的分析造血干细胞移植患者营养状态并进行美国东部肿瘤协作组(ECOG)评分。方法选择2012年6月~2017年3月在陆道培医院接受造血干细胞移植的患者95例为研究对象。采用ECOG评分表对造血干细胞移植患者的体力状态进行评价。记录造血干细胞移植前后患者的体重变化情况。结合ECOG评分和体重变化,分析术后患者的营养状态。比较移植前后血小板(PLT)、红细胞(RBC)、血红蛋白、总蛋白以及白蛋白的变化情况。结果(1)82.11%患者造血干细胞移植后体重下降,17.89%患者体重增加。(2)造血干细胞移植后71.58%患者ECOG评分集中在2~3级,2.10%患者造血干细胞移植前后体力状态未发生变化,4.21%患者术后完全丧失了生活能力。(3)造血干细胞移植后患者PLT和RBC含量显著低于移植前,差异有统计学意义(P<0.05)。结论造血干细胞移植会显著影响患者的营养状态,继而影响患者的生活质量。因此,要重视造血干细胞移植患者术前营养状态并进行适当的营养干预。
Objective To analyze the nutritional status and eastern cooperative oncology group （ECOG） scores of patients underwent hematopoietic stem cell transplantation. Methods From June 2012 to March 2017, 95 patients with hematopoietic stem cell transplantation in Hebei Yanda Lu Daopei Hospital were selected as research objects. ECOG scale was used to evaluate the patients′performance status. The weight of the patients was recorded before and after operation of hematopoietic stem cell transplantation. Nutritional status of patients were analyze on the bases of ECOG scores and weight changes. The platelet （PLT）, red blood cell （RBC）, hemoglobin, total protein and albumin of peripheral blood were compared before and after transplantation. Results ①After operation of hematopoietic stem cell transplantation, 82.11% of patients lost weight, while 17.89% gained weight. ②After transplantation, 71.58% of the patients in ECOG score were concentrated at 2-3 levels, 2.10% of patients had no change in physical status and 4.21% of the patients had totally lost the living ability. ③After transplantation, RBC and PLT in the patients were lower than those of before transplantation, with statistically significant differences （P ＜ 0.05）. Conclusion Hematopoietic stem cell transplantation can significantly affect the nutritional status of patients and subsequently affect the life quality. Therefore, the preoperative of nutritional status should be valued in patients who underwent hematopoietic stem cell transplantation and appropriate nutritional interventions should be taken.
出处
《中国医药导报》
CAS
2017年第35期50-53,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81703221)
农业部食物与营养发展研究所基本科研业务费专项(1610422016003
1610422017007)
关键词
ECOG评分
白血病
营养状态
造血干细胞移植
ECOG score
Leukemia
Nutritional status
Hematopoietic stem cell transplantation
