摘要
大肠癌是一种复杂的疾病,其发生发展涉及多个信号通路的异常。中医药在大肠癌的治疗中发挥了积极的作用,可以通过调控多个信号通路,影响大肠细胞增殖、细胞周期、细胞凋亡、细胞衰老、细胞自噬、化疗耐药、上皮-间质转化、细胞侵袭和转移、血管生成等生物过程,从而发挥治疗的作用。研究显示,藤龙补中汤可以调控p16/p21-Rb信号通路,阻滞大肠癌细胞周期,促大肠癌细胞衰老。斑蝥素、白花蛇舌草、藤龙补中汤等中药可以调控大肠癌细胞凋亡通路,激发大肠癌细胞凋亡。黄芩素、和厚朴酚、左金丸等中药可以调控大肠癌核转录因子（NF）-κB通路,抑制大肠癌细胞增殖、促大肠癌细胞凋亡,增强化疗药的敏感性。澳洲茄胺、苦参碱、透脓散等中药可以调控大肠癌磷脂酰肌醇3激酶（PI3K）/蛋白激酶B（Akt）通路,抑制大肠癌细胞增殖、促大肠癌细胞凋亡。Diterpenoid C,蟾毒灵,凌草乙素等可以调控大肠癌有丝分裂原活化蛋白激酶（MAPK）通路,抑制大肠癌细胞增殖、促大肠癌细胞凋亡或自噬。姜黄素、半枝莲、健脾复方等可以调控大肠癌分泌型糖蛋白（Wnt）/β-链蛋白（β-catenin）通路,抑制大肠癌细胞增殖或转移。去甲斑蝥素、乌索酸、海带多糖等可以调控大肠癌表皮生长因子受体（EGFR）通路,抑制大肠癌细胞增殖,阻滞细胞周期或激发细胞凋亡。氧化苦参碱、健脾解毒方、片仔癀等可以调控转化生长因子（TGF）-β/Smad通路,抑制大肠癌上皮-间质转化和转移。白花蛇舌草、半枝莲、肠复康等可以调控Hedgehog通路,抑制大肠癌血管生成。
Colorectal cancer（ CRC） is a complicated disease. The pathogenesis of CRC is related to the abnormity in multiple signal pathways. Traditional Chinese medicines（ TCM） have played a positive role in treatment of colorectal cancer. TCM can regulate multiple signal pathways,thus have an effect on multitudinous biological processes of CRC cells,such as cell proliferation,cell cycle,apoptosis,cell senescence,autophagy,resistance to chemotherapy,epithelial-mesenchymal transition,cell invasion and metastasis,and contributes to therapeutic effect of TCM against CRC. It has been reported that Tenglong Buzhong decoction（ TLBZT） can regulate p16/p21-RB signaling,arrest cell cycle and induce cell senescence in CRC. Cantharidin,Hedyotidis Herba,TLBZT and other Chinese herbs and medicines regulate apoptotic signal pathways,and induce apoptosis in CRC. Baicalein,Honokiol,Zuojinwan and other Chinese herbs and medicines regulate NF-κB pathway,inhibit cell proliferation,induce apoptosis in CRC,and sensitize CRC cells to chemotherapy. Solasodine,Matrine,Tounong powder and other Chinese herbs and medicines regulate PI3 K/Akt pathway,inhibit cell proliferation,and induce apoptosis in CRC. Diterpenoid C,Bufalin,Ponicidin and other Chinese herbs and medicines regulate MAPK pathway,inhibit cell proliferation,and induce apoptosis or autophagy in CRC. Curcumin,Scutellariae Barbatae Herba,Jianpi formula and other Chinese herbs and medicines regulate Wnt/β-catenin pathway and inhibit cell proliferation or metastasis in CRC. Norcantharidin,Ursolic acid,Laminarin and other Chinese herbs and medicines regulate epidermal growth factor receptor（ EGFR） pathway,inhibit cell proliferation,arrest cell cycle,or induce apoptosis in CRC. Oxymatrine,Jianpi Jiedu recipe,Pien Tze Huang and other Chinese herbs and medicines regulate TGF-β/Smad pathway,and inhibit epithelial-mesenchymal transition and metastasis in CRC.Hedyotidis Herba,Scutellariae Barbatae Herba,Chang-fu-kang and other Chinese herbs and medicines regulate Hedgehog pathway and inhibit angiogenesis in CRC.
作者
王菁雯
沈克平
胡兵
WANG Jing-wen;SHEN Ke-ping;HU Bing(Longhua Hospital, Shanghai University of Traditional Chinese Medicine （ TCM）, Shanghai 200032, China;Institute of TCM in Oncology, Shanghai Academy of TCM, Shanghai 200032, China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2018年第1期227-234,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81473625)
上海市中医药事业发展三年行动计划项目(ZY3-CCCX-3-3025)
上海市科技支撑项目(16401902500)
关键词
大肠癌
中医药
信号通路
细胞活动
colorectal carcinoma
traditional Chinese medicine
signal pathway
cell activity
