摘要
目的:探讨人格特征和血脂水平对心绞痛患者心肌酶的影响。方法:采用调查法对45例不稳定型心绞痛患者、60例稳定型心绞痛患者和50例健康人进行A型和D型人格问卷检测,同时检测血脂、肌钙蛋白(ICTNI)、肌酸激酶同工酶(CKMB)、乳酸脱氢酶(LDH)及乳酸脱氢酶1(LDH_1)水平。结果:与稳定型心绞痛和健康对照组比较,不稳定型心绞痛患者血清高密度脂蛋白水平显著降低;A型人格和D型人格得分、血清心肌酶水平显著升高。血清高密度脂蛋白水平与LDH_1显著负相关,时间紧迫感与血清LDH、LDH_1水平显著正相关,竞争和敌意与血清LDH水平显著正相关;D型人格特征与血清心肌酶水平无显著相关。高密度脂蛋白、时间紧迫感、竞争和敌意对心肌酶的效应值分布在0.125-0.039之间,为中等和较小效应值。结论:血清高密度脂蛋白、时间紧迫感和敌意与冠心病心肌损伤密切相关。
Objective： To examine the effects of personality traits and serum lipid levels on myocardial enzyme of angi- na patients. Methods： Total 155 subjects including 45 unstable angina patients, 60 stable angina patients and 50 healthy individuals were enrolled in the study. Type A personality, type D personality were assessed. Blood samples were taken to assess levels of serum lipid and myocardial enzyme including troponin I（CTNI）, creatine kinase isoenzyme（CKMB）, lactate dehydrogenase（LDH） and lactate dehydrogenasel（LDH1）. Results： Unstable angina patients had lower level of serum highdensity lipoprotein（HDL）, higher sub-dimensions scores of type A and type D, and higher level of serum myocardial enzyme than stable angina patients and the healthy control. HDL was negatively correlated with LDH1, Time Hurry was positively correlated with LDH and LDH1, Competitive and Hostility were positively correlated with LDH. There was no significant as- sociation between type D personality and serum myocardial enzyme level. The η2 of HDL and those personality traits on se- rum myocardial enzyme ranged from 0.125 to 0.039, indicating both HDL and personality traits had medium or small size ef- fects on serum myocardial enzyme levels. Gonclusioa： Lower level of serum HDL, Time Hurry and Hostility of type A per- sonality may contribute to myocardial injury in CHD.
作者
王一赫
杜金玲
Angie LeRoy
刘德祥
吕倩
潘芳
WANG Yi-he;DU Jin-ling;Angle LeRoy;LIU De-xiang;LU Qian;PAN Fang(Department of Neurology, School of Clinical Medicine, Shandong University, Jinan 250012, China;Department of Heart Disease, Qilu Hospital of Shandong University, Jinan 250012, China;Department of Psychology, University of Houston, Houston, TX 77204, U.S.A;Department of Medical Psychology, School of Basic Medical Science, Shandong University, Jinan 250012, China)
出处
《中国临床心理学杂志》
CSSCI
CSCD
北大核心
2017年第6期1048-1053,共6页
Chinese Journal of Clinical Psychology
基金
山东大学高校创新基金(201202227)
关键词
人格特征
心肌酶
血脂
Personality trait
Myocardial enzymes
Lipid
