摘要
尼古丁作用于培养人内皮细胞,引起细胞收缩、胞浆空泡化、质膜泡形成、线粒体及内质网扩张,细胞坏死脱落。受刺激和损伤的内皮细胞Ⅷ因子相关抗原表达增多而纤联素(FN)减少。认为Ⅷ因子相关抗原增多可能导致血小板凝集性上升,促进血栓形成;纤联素减少会导致内皮连接疏松与脱落,在活体可增加内皮通透性、利于血栓形成。上述改变可成为动脉粥样硬化等多种心、脑血管疾病发生发展的促进因素。
Mi and ER of the cultured endothelial cells dilated unedr the effect ofnicotine. The contraction, vacuolation, plasmic vacuole formation and deathof the cells could also be seen. The expressed content of Factor Ⅷ relatedantigen in the injured cells increased and that of fibronectin (FN) decreased.It was suggested that increased Factor Ⅷ related antigen might accelerateplatelet adhensivness and thrombosis while decreased FN might induce endothe-lial cell disconnection or denudation, the latter effect might increase permea-bility and accelerate thrombosis. It was postulated that all the above changeswere responsible for atherosclerosis and the other vascular diseases.
出处
《中国医科大学学报》
CAS
CSCD
1991年第1期27-30,共4页
Journal of China Medical University
