摘要
目的考察NL-101-羟丙基倍他环糊精包合物的制备方法。方法采用冷冻干燥法制备NL-101-羟丙基倍他环糊精包合物,以NL-101包合率为指标,通过正交试验优化包合条件。结果优化的工艺条件为搅拌速度100 r·min-1,搅拌温度10℃,搅拌时间30 min,NL-101:羟丙基倍他环糊精摩尔比为1︰10,按此条件采用冷冻干燥法制备NL-101-羟丙基倍他环糊精包合物,采用X衍射分析和红外光谱法进行确认,表明冷冻干燥后得到了包合物。结论 NL-101与羟丙基倍他环糊精通过冷冻干燥法可形成包合物,按此工艺条件,NL-101-羟丙基倍他环糊精包合物的包合率>95%,同时包合物可提高NL-101的溶解度。
OBJECTIVE To study the preparation of NL-101-hydroxypropyl betacyclodextrin inclusion complex. METHODS The NL-101-hydroxypropylbetadex inclusion complex was prepared by freeze drying method and was optimized with inclusion ratio as index by orthogonal experiment. RESULTS The optimized conditions were 100 r·min-1 of stirring speed, 10 ℃ of stirring temperature, 30 min of stirring time, 1︰10 of ratio of NL-101：hydroxypropyl betacyclodextrin confirmed by X-ray diffraction method and infrared spectroscopy. CONCLUSION NL-101-hydroxypropylbetadex inclusion complex can be effectively prepared with freeze drying method. And the inclusion with greater than 95% of the inclusion ratio is prepared. The solubility of NL-101 is increased when the durg was included by hydroxypropyl betacyclodextrin.
出处
《中国现代应用药学》
CAS
CSCD
2017年第11期1568-1571,共4页
Chinese Journal of Modern Applied Pharmacy
关键词
NL-101
羟丙基倍他环糊精
包合
包合率
冷冻干燥
NL- 101
NL- 101-hydroxypropylbetadex
inclusion complex
inclusion ratio
freeze drying
