摘要
目的探讨缺血性脑卒中患者血清中氧化低密度脂蛋白(ox-LDL)和脂蛋白相关磷酯酶A2(Lp-PLA2)水平与颈动脉粥样硬化及神经功能缺损的相关性。方法选取2015年2月至2017年2月新疆维吾尔自治区中医院老年病收治的急性脑梗死患者135例(ACI组)和同期医院住院患者150例(对照组),所有入选者均对血清中的ox-LDL、Lp-PLA2水平进行检测,比较ACI组和对照组的血清ox-LDL、Lp-PLA2及其他血脂指标水平;行颈动脉超声检查,对无斑块组、稳定斑块组和不稳定斑块组患者的ox-LDL、Lp-PLA2水平进行比较;按美国国立卫生研究院卒中量表(NIHSS)评分,对轻型、中型、重型患者的ox-LDL、LpPLA2水平进行比较。结果 ACI组的血清ox-LDL、Lp-PLA2水平均高于对照组,差异具有统计学意义(P<0.01);稳定斑块组、不稳定斑块组血清ox-LDL、Lp-PLA2水平高于无斑块组,差异具有统计学意义(P<0.05);不稳定斑块组血清ox-LDL、LpPLA2水平高于稳定斑块组,差异具有统计学意义(P<0.05);NIHSS评分中型、重型血清ox-LDL、Lp-PLA2水平均高于轻型,差异具有统计学意义(P<0.05);重型血清ox-LDL、Lp-PLA2水平显著性高于中型,差异具有统计学意义(P<0.05)。结论 oxLDL、Lp-PLA2可作为急性缺血性脑血管病的血清标记物,在评估急性缺血性脑血管病的病情及预后方面有一定的临床意义。
Objective To investigate the association of oxidized low density lipoprotein （ox-LDL） in the serum and lipoprotein associated phospholipase A2 （Lp-PLA2） levels with carotid atherosclerosis and neurologic impairment in patients with cerebral ischemic stroke. Methods 135 patients with acute cerebral infarction （ACI group） and 150 cases inpatients （control group） from February 2015 to February 2017 in the Traditional Chinese Medicine Hosptical of Xinjiang Uygur Autonomous Region were selected to detect serum ox-LDL and Lp-PLA2 levels,and serum ox-LDL,Lp-PLA2 and other levels of blood lipid index were compared between ACI group and control group ; carotid artery ultrasonography was conducted, ox-LDL and Lp-PLA2 levels of non plaque group,stable plaque group and unstable plaque group were compared; ox-LDL and Lp-PLA2 levels of mild,moderate and severe patients according to the score of the National Institutes of Health Stroke Scale （NIHSS） were compared. Results The serum ox- LDL and Lp-PLA2 levels of ACI group were higher than those in the control group,and the difference was statistically significant （P〈0. 01） ;serum ox-LDL？Lp-PLA2 levels of stable plaque and unstable plaque were significantly higher than those of non plaque group （P〈0. 05）; serum ox-LDL, Lp-PLA2 levels of unstable plaque were higher than those of the stable plaque group （P〈0. 05） ; serum ox-LDL and Lp-PLA2 levels of moderate and severe patients determined by the NIHSS score were significantly higher than that of mild patients （P 〈 0. 05） ;serum ox-LDL and Lp-PLA2 levels of severe patients were significantly higher than that of moderate patients （P〈0. 05）. Conclusion Serum ox-LDL and Lp-PLA2 levels of patients with cerebral ischemic stroke increased significantly compared with the normal people？ which reflects the severity of carotid atherosclerosis and neurologic impairment. ox- LDL and Lp-PLA2 levels can be used as a serum marker of acute ischemic cerebrovascular disease,has certain clinical significance in evaluating the severity and prognosis of acute ischemic cerebrovascular disease.
出处
《国际检验医学杂志》
CAS
2017年第23期3283-3285,共3页
International Journal of Laboratory Medicine
基金
基金项目:新疆维吾尔自治区中医民族医药管理局(2016-04-03)
