摘要
目的分析白介素-6(IL-6)和Dkk1抗原检测在骨髓瘤骨病患者中的临床意义。方法 39例骨髓瘤骨病患者作为观察组,39例健康人作为对照组。采用酶联免疫吸附法和化学发光法检测两组血清IL-6和Dkk1水平。结果 (1)观察组IL-6和Dkk1水平分别为(23.13±0.62)μg/L、(9.10±6.75)pg/L,高于对照组(4.69±0.51)μg/L、(2.96±1.54)pg/L,差异有统计学意义(P<0.05)。(2)观察组Ⅰ期IL-6和Dkk1水平分别为(6.15±0.70)μg/L、(3.12±0.77)pg/L,观察组Ⅱ期IL-6和Dkk1水平分别为(12.68±0.66)μg/L、(8.94±1.56)pg/L,观察组Ⅲ期IL-6和Dkk1水平分别为(26.33±0.48)μg/L、(15.61±1.76)pg/L,IL-6和Dkk1表达水平随着临床分期增加而逐渐升高,IL-6和Dkk1水平与临床分期相关,观察组Ⅰ期、Ⅱ期、Ⅲ期患者IL-6和Dkk1水平比较,差异有统计学意义(P<0.05)。(3)观察组患者IL-6和Dkk1共同阳性30例,占76.92%;IL-6和Dkk1共同阴性9例,占23.08%;阳性和阴性表达成正相关(r=0.741 5,P=0.021 5)。结论 IL-6和Dkk1检测在骨髓瘤骨病患者中的临床意义较大,可作为早期诊断指标。
Objective To analyze the clinical significance of IL-6 analysis and Dkk1 detection in myeloma patients. Methods 39 cases of myeloma patients as the study group,39 healthy people as control group. Using enzyme-linked immunosorbent assay and chemiluminescence method of serum IL-6 and the expression of Dkk1 in the control group and the study group for the study. Results The expression of Dkk1 and IL-6 respectively( 4. 69 + 0. 51) μg/L,( 2. 96 + 1. 54) pg/L,Dkk1 and IL-6 in the study group were( 23. 13 + 0. 62 μg/L),( 9. 10 + 6. 75) pg/L,Dkk1 and IL-6 in the study group was significantly higher than the control group: The difference was statistically significant( P < 0. 05). The study groupⅠIL-6 and Dkk1 expression was respectively( 6. 15 + 0. 70) μg/L,( 3. 12 + 0. 77) pg/L,Ⅱin the study group IL-6 and Dkk1 was respectively( 12. 68 + 0. 66) μg/L,( 8. 94 + 1. 56) pg/L,Ⅲ in the study group IL-6 and Dkk1 was respectively( 26. 33 + 0. 48) μg/L,( 15. 61 + 1. 76) pg/L,IL-6 and Dkk1 expression was with clinical staging,IL-6 and Dkk1 expression was with clinical stage compliance. Study groupⅠ period,Ⅱ period,Ⅲ period in patients with IL-6 and Dkk1 expression were statistically significant( P < 0. 05); the study group in patients with IL-6 and Dkk1 was positive in 30 cases,accounting for76. 92%; IL-6 and Dkk1 patients in 9 cases were negative,accounting for 23. 08%. The positive and negative expression were significantly positive correlation( r = 0. 741 5,P = 0. 021 5). Conclusion The clinical significance of IL-6 and Dkk1 in myeloma and bone disease is relatively large and can be used as an early diagnostic indicator.
出处
《河南医学高等专科学校学报》
2017年第6期595-598,共4页
Journal of Henan Medical College
关键词
骨髓瘤骨病
IL-6
DKK1
检测
临床意义
myeloma patients with bone disease
IL-6
Dkk1
detection
clinical significance
