摘要
目的探讨定量CT纹理分析鉴别透明细胞型肾癌和非透明细胞型肾癌的可行性。方法回顾性分析100个透明细胞型肾癌和27个非透明细胞型肾癌病灶的CT图像,应用TexRAD软件分析各扫描期相两种类型肾癌的纹理特征。结果增强图像上,非透明细胞型肾癌的平均灰度值、标准差、熵、正像素的平均值明显低于透明细胞型肾癌,而峰度高于透明细胞型肾癌(P均<0.001),偏度差异无统计学意义(P>0.05)。在皮髓质期的粗糙纹理上,正像素的平均值鉴别两种类型肾癌的ROC曲线下面积为0.92±0.04,敏感度为0.85,特异度为0.93,准确率为0.87。结论透明细胞型肾癌与非透明细胞型肾癌的CT纹理特征间存在显著差异,定量CT纹理分析鉴别诊断这两种类型肾癌具有临床价值。
Objective To explore the value of CT texture analysis （CTTA） in differential diagnosis of non clear-cell renal cell carcinoma （non-ccRCC） and clear-cell renal cell carcinoma （ccRCC）. Methods A total of 100 ccRCC and 27 non-ccRCC lesions were retrospectively analyzed. CTTA was performed on multiphasic CT images by using TexRAD software, and texture features were compared between ccRCC and non-ccRCC. Results Compared with ccRCC, the mean and standard deviation, entropy as well as the mean of positive pixels （MPP） were significantly lower, while kurtosis was higher in non-ccRCC lesions on enhanced CT images （P〈0.001）. No significant difference was observed in skewness between non-ccRCC and ccRCC （P〉0.05）. MPP at coarse texture scale on corticomedullary images identified non-ccRCC from ccRCC with an AUC of 0.92±0.04, the sensitivity was 0.85, specificity was 0.93 and accuracy was 0.87. Conclusion There are significant differences in CTTA parameters between non-ccRCC and ccRCC. CTTA has clinical value in differential diagnosis of non-ccRCC and ccRCC.
出处
《中国医学影像技术》
CSCD
北大核心
2017年第12期1768-1773,共6页
Chinese Journal of Medical Imaging Technology
基金
卫生部行业基金科研专项(201402019)
关键词
癌
肾细胞
体层摄影术
X线计算机
纹理分析
Carcinoma, renal cell
Tomography, X-ray computed
Texture analysis
