摘要
本文研究了A-OT-Fu与1.5%淀粉液研磨成胶状及混合成颗粒状的两种不同粒度的制剂均,按290mg/kg剂量分别给小鼠灌胃后,对其代谢物血药浓度的影响。实验结果表明,A-OT-Fu的胶体状制剂吸收快,血药浓度高,达峰时间旱。其颗粒状的制剂吸收慢,血药浓度低,达峰时间晚。
A-OT-FU powder was grinded and dispersed in1.5% starch paste to a colloidal or particulatestate. 290 mg/kg of two different granular sizepreparations was given to mice. The effects of A-OT-Fu granular size on the serum concentration ofmetabolites in mice were studied. The resultsshowed that the colloidal preparation of A-TO-FUwas absorbed fast, with a high serum concentration and early peak time, whereas the particulate prepa-ration of A-OT-FU was absorbed slowly with alowserum concentration and late peak time.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1991年第12期726-728,共3页
Chinese Pharmaceutical Journal
关键词
血药浓度
抗癌药
阿托氟尿嘧啶
A-OT-Fu
granular size
serum concentration
effect
