摘要
目的:探索中国人群脂联素基因外显子rs2241766多态性与糖尿病易感性的关系。方法:全面检索国内外数据库,搜集有关中国人群的符合纳入和排除标准的文献。根据糖尿病组与对照组人群脂联素基因rs2241766位点GG、GT和TT 3种基因型频数,使用无遗传模式法的广义OR值(GOR)评价该位点多态性与糖尿病的关联性。结果:共纳入文献41篇。糖尿病患者7 142例,对照组6 588例。研究间存在异质性(I^2=76.30%,P<0.001),故选择随机效应模型,GOR(95%CI)为1.16(1.01~1.31),提示rs2241766位点G等位基因是中国人群糖尿病患病危险因素。Meta回归分析结果表明糖尿病组平均年龄和样本量是异质性主要来源,研究无发表偏倚,敏感性分析也表明结果稳定。结论:rs2241766位点G等位基因是中国人群糖尿病患病危险因素。
Aim： To explore the association between adiponectin gene exon rs2241766 polymorphism and susceptibility of diabetes mellitus（ DM） in Chinese population. Methods： An extensive data about Chinese population and DM were retrieved and screened in accordance with the inclusion and exclusion criteria from the scientific databases. Based on the frequencies of GG,GT and TT genotypes in case and control groups,generalized OR（ GOR） was calculated and applied to evaluate whether the G allele was a risk factor for DM in Chinese population. Results： There were 41 literatures retrieved in this research,which included 7 142 DM patients and 6 588 controls. There was heterogeneity among studies,thus a random-effect model was chosen. GOR（ 95% CI） was 1. 16（ 1. 01-1. 31）,indicating that G allele was a risk factor for DM in Chinese people. In meta-regression analysis,the heterogeneity could be explained by sample size and the mean age of DM patients. There was no publication bias in the current study and sensitivity analysis also suggested robust stability of the results. Conclusion： The adiponectin exon rs2241766 polymorphism is a risk factor for DM in Chinese population.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2017年第6期711-717,共7页
Journal of Zhengzhou University(Medical Sciences)
基金
国家自然科学基金项目81001280
81202277
河南省高等学校重点科研项目计划16A330003
河南省科技攻关计划项目172102310373
