摘要
对羟基苯丙酮酸双加氧酶(EC 1.13.11.27,HPPD)是重要的除草剂靶标.以HPPD为靶标的除草剂具有高效、低毒、作物安全性高、不易产生抗性、环境相容性好及对后茬作物安全等一系列优点.结合最新的研究进展,详细综述了HPPD的结构,并针对吡唑类HPPD除草剂的作用模式、在生物体内的作用机制和代谢途径以及研究现状进行了总结与分析.
4-Hydroxyphenylpyruvate dioxygenase（HPPD）,a target for green herbicide discovery,has recently attracted a large number of famous scientists attention owing to controlling efficacy of resistant weeds.The structures of HPPD,inhibitors binding sites,mode of action and their metabolites are summarized.The current commercial and developing pyrazole-containing herbicides of HPPD are analyzed.Based on combining theory and practical application,a direction to find or design a new inhibitor is also oriented.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2017年第11期2895-2904,共10页
Chinese Journal of Organic Chemistry
基金
国家科技支撑计划(No.2014BAD20B01)
国家自然科学资金基金(Nos.21372093
21672079)
中国高校基本科研业务费(No.CCNU15A02011)资助项目~~
