摘要
基因组DNA经过转录可以产生两大类RNA,编码蛋白的RNA和非编码RNA(noncoding RNA,ncRNA)。其中,长链非编码RNA(lncRNA)受到了越来越多的关注。lncRNA可以通过多种机制,从转录水平,转录后水平以及表观修饰水平调节靶基因的表达,进而调控肌肉与脂肪的发育。本文将对lncRNA的基本特征及功能机制进行介绍,综述lncRNA对肌肉和脂肪组织发育的调控机制,并对lncRNA未来的研究进行展望,为研究者在lncRNA方面的研究提供有力的参考。
Genome DNA can transcribe two broad categories of RNA, including protein coding RNA and noncoding RNA （ncRNA）. The lncRNA （long noncoding RNA）, belonging to ncRNA, gets more and more attention. LncRNA could regulate target functional gene expression levels in many ways, such as the transcriptional level, post--transcriptional level or epigenetic modifications control, further to regulate the development of muscle and fat. This paper introduced the basic characteristics and functional mechanisms of lncRNA, and reviewed the regulation mechanisms of IncRNA in the development of muscle and fat as well as provided an outlook for the future about the research of lncRNA, which would provide useful refer- ence for researchers.
出处
《中国牛业科学》
2017年第5期38-43,共6页
China Cattle Science
基金
国家自然科学基金(面上项目)(No.31672400)
西北农林科技大学国际合作种子基金项目(2017-2018)
国家肉牛牦牛产业技术体系(CARS-37)
国家级大学生科创项目(No.201610712016)资助
