摘要
目的探讨趋化因子巨噬细胞炎性蛋白（MIP-1）α、MIP-1β在甲状腺乳头状癌发生发展中的作用。方法收集2014年1月至2016年10月于我院就诊的甲状腺疾病患者120例，其中甲状腺乳头状癌60例（实验组），良性甲状腺疾病60例（对照组）。利用ELISA法检测患者血清MIP-1α、MIP-1β的表达水平。手术切除标本常规制作石蜡包埋切片，分析MIP-1α、MIP-1β的表达特点。结果MIP-1α、MIP-1β蛋白定位于甲状腺上皮细胞质，在癌组织中的表达阳性率显著高于良性甲状腺肿块组织。实验组血清中MIP-1α、MIP-1β的表达水平明显高于对照组，差异有统计学意义（P＜0.05）。结论MIP-1α、MIP-1β可能参与了甲状腺乳头状癌的发生发展，有可能作为甲状腺乳头状癌监测和治疗的新靶点。
ObjectiveTo investigate the role of MIP-1α and MIP-1β in the development and progression of papillary thyroid carcinoma. MethodsA total of 120 patients with thyroid diseases who were admitted into our hospital from January 2014 to October 2016 were enrolled. They were divided into two groups： an experimental group （60 patients with thyroid papillary carcinoma） and a control group （60 patients with benign thyroid disease） were collected. Then, the levels of serum MIP1α and MIP-1β were measured by ELISA. Paraffin-embedded sections were prepared to analyze their expression characteristics in both groups. ResultsThe expression of MIP-1α and MIP-1β protein were found in the cytoplasm of thyroid epithelial cells. The positive rates of MIP-1α and MIP-1β expression were significantly higher than those in benign thyroid tumor. The experimental group produced remarkable higher amounts of serum MIP-1α and MIP-1β, compared with the control group （P〈0.05）. ConclusionsMIP-1α and MIP-1β may be involved in the development of papillary thyroid carcinoma and may serve as a new target for the papillary thyroid carcinoma.
出处
《徐州医科大学学报》
CAS
2017年第11期725-728,共4页
Journal of Xuzhou Medical University
基金
上海市闵行区自然科学基金（2017MHZ32）
上海市闵行区卫生和计划生育委员会科研课题（2014MW05）
