摘要
目的探讨CD64指数和降钙素原(PCT)对恶性血液病合并细菌感染的早期诊断价值。方法选取2014年1月-2017年5月收治的恶性血液病患者作为研究对象,其中感染组86例,非感染组78例,感染组又分为革兰阴性菌感染组和革兰阳性菌感染组,选取同一时期健康体检者100例作为对照组,比较分析各组患者CD64和PCT水平变化,并就CD64和PCT对恶性血液病合并细菌感染的诊断效能和相关性进行分析。结果革兰阴性菌感染组CD64和PCT水平明显高于革兰阳性菌感染组;感染组CD64和PCT水平较对照组和非感染组均明显升高,经治疗后CD64和PCT水平均显著下降;感染组CD64和PCT的阳性率显著高于对照组和非感染组,以上差异均有统计学意义(P<0.05)。相关性分析表明,CD64和PCT之间呈正相关(r=0.816,P<0.01)。结论 CD64和PCT能够作为恶性血液病合并细菌感染的诊断指标,对细菌感染的早期诊断与治疗具有重要的临床意义。
Objective To investigate the value of peripheral blood neutrophil CD64 index and procalcitonin（ PCT） in the early diagnosis of malignant hematologic malignancies with bacterial infection. Methods Hematological malignancies cases were selected from January 2014 to May 2017 as the research objects,including infection group（ 86 cases）,non-infection group（ 78 cases）,and the infection group was divided into gram-negative bacteria infection group and gram-positive bacteria infection group,at the same time,100 cases of healthy subjects were selected as the control group. Changes of CD64 and PCT levels in each group were compared,and the diagnostic efficacy and correlation of CD64 and PCT in the diagnosis of malignant hematologic malignancies merged with bacterial infection were analyzed. Results CD64 and PCT levels in gram-negative bacteria infection group were significantly higher than gram-positive bacteria infection group; the levels of CD64 and PCT in the infection group were significantly higher than those in the healthy control group and non-infection group; after treatment,the levels of CD64 and PCT significantly decreased; the positive rates of CD64 and PCT in infection group were significantly higher than that in the control group and the non-infection group,with the differences statistically significant（ P〈 0. 05）. Correlation analysis showed a positive correlation between CD64 and PCT（ r = 0. 816,P〈 0. 01）. Conclusion CD64 and PCT can be used as a diagnostic index for malignant hematologic disease with bacterial infection,and has important clinical significance on the early diagnosis and treatment of bacterial infection.
出处
《中国卫生检验杂志》
CAS
2017年第21期3111-3113,3117,共4页
Chinese Journal of Health Laboratory Technology
基金
衢州市科技局科技计划项目(2015064)
关键词
中粒细胞CD64指数
降钙素原
恶性血液病
细菌感染
早期诊断
Granuloeyte CD64 index
Procalcitonin
Malignant hematologic disease
Bacterial infections
Early diagnosis
