摘要
目的:观察清热化瘀方联合西药治疗缺血性中风的临床疗效。方法:将192例缺血性中风患者随机分为治疗组与对照组。治疗组予西医基础治疗+清热化瘀方颗粒剂;对照组给予基础治疗+吡拉西坦片,28 d为1个疗程。观察两组患者治疗前后的神经功能缺损积分(NIHSS)、运动功能积分(FMA)、生活质量积分(QLI)、中医证候积分和血清白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)含量的变化。结果:总有效率治疗组为94.4%,对照组为83.3%,治疗组优于对照组(P<0.05)。治疗后治疗组中医证候积分低于对照组(P<0.05)。两组患者治疗后NIHSS评分均较治疗前降低(P<0.05),FMA、QLI评分均较治疗前增加(P<0.05),且治疗组治疗后NIHSS评分低于对照组(P<0.05),FMA、QLI评分高于对照组(P<0.05)。两组患者治疗后血清IL-1β、TNF-α含量均降低(P<0.05),且治疗组治疗后血清IL-1β、TNF-α含量均低于对照组(P<0.05)。结论:清热化瘀方联合西药治疗缺血性中风患者疗效确切。
Objective： To observe the effect of ischemic stroke adopting combined treatment of Qingre Huayu Prescription（清热化瘀方,QRHYP） and regular western medicine therapy to attempt to discuss its therapeutic mechanism.Methods： The 192 cases of ischemic stroke patients were randomly divided into treatment group and control group.Then control group was given regular western medicine therapy and piracetam,while treatment group was given regular western medicine therapy and QRHYP.After the treatment of 28 days,we observed the changes of NIHSS（The National Institutes of Health Stroke Scale）,FMA（Fugl-Meye）,QLI（Quality of Life Index） and SDS（TCM syndrome score）.At the same time,the concentrations of blood IL-1β and TNFa were measured in patients before and after therapy.Results： The total effective rate was 94.44% in the treatment group,while the total effective rate was 83.33% in the control group.There was significantly difference between them（P〈0.05）.After treatment,the improvement of symptoms in treatment group was significantly better than that of control group（P〈0.05）.All of NIHSS,FMA and QLI scales revealed that the scores significantly improved after treatment.There was significantly difference（P〈0.05） between pre-therapy and post-treatment,and the treatment group was superior to the control group（P〈0.05）.After 28 days,the concentrations of blood IL-1βsignificantly decreased in both groups（P〈 0.05）,and the treatment group was superior to that in the control group（P 〈0.05）.Conclusion： This study showed that combined Qingre Huayu Prescription and regular western medicine therapy had curative effect in the treatment of acute ischemic stroke through down-regulating the expression of IL-1β and TNF-α.
出处
《中医药导报》
2017年第20期79-81,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
广西中医药管理局中医药民族医药传承创新专项课题(No.GZLC14-01)
关键词
缺血性中风
风火痰瘀痹阻证
清热化瘀方
临床疗效
ischemic stroke
wind-phlegm and blood stasis in collaterals
Qingre Huayu prescription
curative effect
