摘要
在家兔离体工作心脏模型上,观察MFA对心脏的直接作用及对心肌缺血再灌注损伤的保护作用。结果发现MFA 2.5,5,10和20μmol/L灌注心脏10min,剂量依赖性地抑制心功能参数并增加冠脉流量;MFA 2.5,5和10μmol/L对60min缺血30min再灌注所致的心肌损伤有保护作用,增加心功能参数的恢复并降低细胞内CPK外漏。
The effects of methylflavonolamine (MFA) on global myocardial ischemia-reperfused injury were studied in the isolated working rabbit hearts. MFA (2.5-20 μmol/L) dose-dependently inhibited cardiac function parameters and increased coronary flow. MFA, at the concentration of 2.5-10 but not 20 μmol / L, cardiac functional parameter of the isolated working rabbit hearts injured by 60 min low-flowischemia and 30 min reperfusion; prevented the development of contracture and reduced the release of CPK from the reperfused hearts.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1991年第1期21-23,共3页
Chinese Journal of Pharmacology and Toxicology
关键词
甲基黄酮醇胺
心肌缺血
保护作用
methylflavonolamine
ischemia
reperfusion
isolated heart
hemodynamics
creatine kinase
