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多西紫杉醇和顺铂联合三维适形放疗治疗中晚期食管癌 被引量:4

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摘要 目的探讨多西紫杉醇和顺铂联合三维适形放疗治疗中晚期食管癌的临床疗效。方法 52例中晚期食管癌患者根据干预方案不同分为对照组(n=26)和研究组(n=26)。研究组采用多西紫杉醇和顺铂联合三维适形放疗治疗,对照组仅采用三维适形放疗。结果研究组总有效率(84.61%)高于对照组(57.70%),差异有统计学意义(P<0.05);研究组白细胞减少发生率(42.31%)、血小板减少发生率(38.46%)、胃肠道反应发生率(46.15%)均高于对照组(15.38%、11.54%、15.39%),差异均有统计学意义(P均<0.05)。研究组1 a生存率(84.62%)与对照组(80.77%)比较差异无统计学意义(P>0.05),而研究组2 a生存率(69.23%)高于对照组(38.46%),差异有统计学意义(P<0.05)。结论多西紫杉醇和顺铂联合三维适形放疗治疗中晚期食管癌疗效确切,可有效提高临床疗效,改善中期生存,不良反应发生率虽较高,但均可耐受。
出处 《肿瘤基础与临床》 2017年第5期432-434,共3页 journal of basic and clinical oncology
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