摘要
目的探讨结缔组织病(Connective Tissue Diseases,CTD)合并肺部真菌感染的临床特点、相关危险因素;方法将2015年1月至2015年12月我科住院患者中确诊为CTD 201例,分为真菌感染组(n=22)和非感染组(n=179),分别对性别、年龄、病程、使用抗生素、激素、免疫抑制剂以及实验室检查等危险因素进行Logistic回归分析;结果单因素分析显示年龄、病程、糖皮质激素(日剂量大于30mg)、免疫抑制剂、广谱抗生素的使用、血沉快、白细胞减少、低蛋白血症是CTD合并肺部真菌感染的危险因素,多因素Logistic回归分析中年龄、糖皮质激素(日剂量大于30mg)、免疫抑制剂、广谱抗生素的使用是CTD合并真菌感染的独立危险因素;结论年龄、激素(日使用剂量超过30mg)、免疫抑制剂、广谱抗生素的使用是CTD合并肺部真菌感染的高危因素。
Objective To explore the characteristics of hosjDitalized connective tissue disease （ CTD） pa-tients witli pulmonary fungal infection and identify the risk factors. Metliods The files of 201 CTD patients ted to our hospital from January 2015 to December 2015 were retrospectively reviewed. A total of 22 CTD patientswithi pulmonary fungal infection were enrolled into this study and asigned to the experimefected CTD patients were assigned to the control group. Their age, gender, disease course, use of antibiotics and laboratory indicators were recorded and risk factors were calculated by logistical regressioResults The univariate analysis showed that the age,disease course, application of glucocorticoid （ 〉30mg/D）,use of antibiotics and immunosuppressant, increase of erythocyte sedimen, leukopenia, and hypoproteinemia were the risk factors for CTD patients with pulmonary fungal infection. The multivariate logistic regression analysis showedage,application of glucocorticoid （ 〉 30mg/D）, use of antibiotics and immunosuppressant were the independent riskfactors for CTD patients witli pulmonary fungal infection. Conclusion The risk factors of fungaltients include elder age, application of glucocorticoid witli more than 30mg daily pressant and broad-sjDectrum antilbiotics.
出处
《临床肺科杂志》
2017年第12期2178-2181,共4页
Journal of Clinical Pulmonary Medicine
关键词
结缔组织病
肺部真菌感染
危险因素
connective tissue disease
pulmonary infection
risk factors
