摘要
目的探讨CD56抗原与老年急性髓系白血病患者疗效及预后的相关性。方法选取138例老年急性髓系白血病患者进行前瞻性研究,根据CD56抗原表达情况分为阳性组(74例)与阴性组(64例)。所有患者治疗方案均为蒽环类药物联合阿糖胞苷,比较阳性组与阴性组患者的完全缓解率、无病生存时间(DFS)、总生存时间(OS)、3年DFS率与3年OS率,对CD56抗原表达与患者DFS、OS进行相关性分析。结果阳性组与阴性组患者的完全缓解率分别为86.49%、93.75%,差异无统计学意义(χ~2=0.993,P=0.319)。阳性组DFS与OS分别为(1.64±0.57)年、(2.70±0.81)年,均短于阴性组(t=2.026,P=0.047;t=2.050,P=0.044),3年DFS率与OS率分别为22.22%、38.89%,均低于阴性组(χ~2=4.600,P=0.032;χ~2=4.848,P=0.028)。CD56抗原表达与DFS(r=0.425,P=0.002)、OS(r=0.557,P=0.000)均有显著正相关,与复发情况之间呈显著负相关(r=-0.756,P=0.001),阳性患者的复发风险更大。结论 CD56抗原表达与老年急性髓系白血病患者预后之间存在明显相关性,表现为CD56抗原阳性患者DFS与OS短于阴性患者,复发率更高。
Objective To investigate the correlation between CD56 antigen and the prognosis and prognosis of elderly patients with acute myeloid leukemia. Methods 138 elderly patients with acute myeloid leukemia were selected,and divided into positive group（ 74 cases） and negative group（ 64 cases） according to the CD56 antigen expression. All patients were treated with anthracycline combined with cytarabine. The complete remission rate,disease-free survival time（ DFS）,total survival time（ OS）,3-year DFS rate and 3-year OS rate were compared between the positive group and the negative group,the correlation of the expression of CD56 antigen with DFS and OS in patients were analyzed. Results The complete remission rate of positive and negative group was 86. 49% and 93. 75%,the difference was not statistically significant（ χ^2=0. 993,P = 0. 319）. The DFS and OS in positive group were（ 1. 64 ± 0. 57） years,（ 2. 70 ± 0. 81） years,which were shorter than those in the negative group（ t = 2. 026,P = 0. 047; t = 2. 050,P = 0. 044）. The 3 years DFS rate and OS rate in positive group were 22. 22%,38. 89%,which were lower than those in negative group（ χ^2= 4. 600,P = 0. 032; χ^2= 4. 848,P = 0. 028）. The expression of CD56 antigen was significantly positive correlated with DFS（ r = 0. 425,P = 0. 002） and OS（ r = 0. 557,P = 0. 000）,and there was a significant negative correlation with recurrence（ r =-0. 756,P = 0. 001）,the patients CD56 positive expression were easier to relapse. Conclusion There is a significant correlation between the expression of CD56 antigen and the prognosis of elderly patients with acute myeloid leukemia. The DFS and OS of CD56 antigen positive patients are shorter than those of negative patients,and the recurrence rate is higher.
出处
《临床和实验医学杂志》
2017年第21期2125-2128,共4页
Journal of Clinical and Experimental Medicine
关键词
急性髓系白血病
老年
CD56抗原表达
无病生存时间
总生存时间
Acute myeloid leukemia
Elderly
CD56 antigen expression
Disease - free survival time
Total survival time
