摘要
β丁香烯醇是艾叶油的平喘有效成分β丁香烯经胃-肠液转化后的化合物。它对豚鼠药物性哮喘具有保护作用,作用强而持久。对豚鼠离体气管平滑肌有直接松弛作用。能抑制致敏豚鼠肺组织SRS-A的释放和拮抗SRS-A作用,并有镇咳、祛痰作用。本品是一平喘作用强而持久的新平喘化合物。
β-caryophyllene was one of the effective antiasthmatic principles of essential oil of Artemisia argyi, by way of structural modification to form β-caryophyllene alcohol. P-caryophyllene alcohol could protect acetylcholine and histamine-induced asthma in guinea pig, and the effect was longer than 4h. It had relaxant effect on isolated guinea pig tra.cheal smooth muscle prepareations, and the pD2 values was 4.36 + 0.37. The drug not only significantly inhibited antigen induced release of SRS-A in the lung fragments of sensitized guinea pig( ID50 23mg/L ), but also inhibited SRS-A induced contraction of the guinea pig ileum(ID50 18mg/L). In addition, P-caryophyllene alcohol had antitussive and expectora'at actions. These results show that p-caryophyllene alcohol is a new antiathmatic drug.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第2期145-148,共4页
Chinese Pharmacological Bulletin
关键词
β丁香烯醇
严喘
抗过敏
β-caryophyllene alcohol
Guinea pig tracheal smooth muscle
Antiasthmatic effect
Antianaphylactic effect
