摘要
巴马汀(Pal,50μmol/L)可使离体豚鼠右心室乳头肌的自律性降低、功能不应期(FRP)延长,但对兴奋性和收缩力无明显影响。Pal(10～100μmol/L)是浓度依赖性地延长动作电位时程(APD),其中APD_(90)延长比较显著。100μmol/L时,还使V_(max)降低。
The mechanism of antiarrhythmic effects of palmatine( Pal), an benzoquinolizine compound were studied in experimental animals.
In the isolated guinea pig papillary muscles, Pal 50 μmol/L markedly prolonged the functional refractory period(FRP)and decreased the automaticity induced by adrenaline, but exerted no effect on excitabj- iity and contractility of the muscles.
Pal(10 μmol/L ) prolonged both APD20 and APD90 of the action potential of guinoa pig papillary muscles. The Vmax was decreased at 100 μmol/L Pal, but the action potential amplitude( APA ) and resting potential ( RP ) were unaltered.
The antiarrhythmic action of Pal may be due to its ability to decrease automaticity and to proloagate FRP and APD of the myocardium.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第2期138-141,共4页
Chinese Pharmacological Bulletin
关键词
巴马汀
抗心律失常药
动作电位
Palmatine
Action potential
Excitability
automaticity
Contractility
FRP
