摘要
目的探讨甲状腺结节与代谢综合征(metabolic syndrome;MS)及其组成成分之间的相关性。方法回顾医院内分泌门诊及体检中心共7821例资料,通过B超检查分甲状腺结节组与非甲状腺结节组,比较2组体重指数、空腹血糖、血压、血脂等指标。将单因素分析筛选出的可能危险因素进一步进行多因素Logistic回归分析,评价甲状腺结节与MS及其组成成分之间的相关性。结果甲状腺结节患病率和MS患病率均随年龄增长而增加,甲状腺结节组的MS患病率较非甲状腺结节组明显升高(8.3%VS 5.2%);差异均有统计学意义(P<0.05)。Logistic回归分析显示,性别(女性)为首要正相关因素(OR=1.643),其次为年龄(OR=1.048)、空腹血糖(OR=1.030)、低密度脂蛋白(OR=1.008),而非MS患者(OR=0.889)为负相关因素。通过确定Logistic回归模型,根据计算预测概率公式绘制ROC曲线,AUC=0.586,与AUC=0.500比较,差异有统计学意义(P<0.01)。结论 MS个体甲状腺结节患病率显著增高,其中性别、年龄、空腹血糖、密度脂蛋白水平和血清总胆固醇是甲状腺结节发生的独立危险因素。
Objective To examine the correlation between thyroid nodule and metabolic syndrome and the influential factors.Method The clinical data of 7821 patients were firstretrospectively reviewed. The subjects were then divided into two groups in light of results of B ultrasonic examination,namely,thyroid nodule group and non-thyroid nodule group. The body mass index,fasting blood glucose,blood pressure,blood lipid and so on of both groups were then compared. Single factor analysis into the possible risk factors were next conducted to determine the correlation between thyroid nodule and MS and its factors by logistic regression analysis. Findings The prevalence of both thyroid nodules and MS increased as the age increased. The rate of occurrence of MS in the thyroid nodule group was significantly higher than that of non-thyroid nodule group（ 8.3% vs 5. 2%,P〈0. 05）. Logistic regression analysis showed that gender（ female） was the primary positive correlation factor（ OR = 1. 643,95% CI = 1. 383 ~ 1. 950）,followed by age（ OR = 1. 048,95% CI = 1. 042 ~ 1. 054）,fastingglucose（ OR = 1. 030,95% CI = 1. 005 ~ 1.055）,low-density lipoprotein（ OR = 1.008,95% CI = 1.003 ~ 1.014）,while nonMS patients（ OR = 0. 889,95% CI = 0. 791 ~ 0. 998） were negative related factors. By determining the Logistic regression model,the ROC curve was plotted according to the calculating predicted probability formula,AUC = 0. 586. Compared with AUC = 0. 500,the difference was statistically significant（ P0. 01）. Conclusion The rate of prevalence of thyroid nodules in MS individuals is significantly higher. Age,fasting blood glucose,density lipoprotein level and serum total cholesterol are independent risk factors contributing to the formation of thyroid nodules.
出处
《健康研究》
CAS
2017年第5期484-487,共4页
Health Research
基金
瑞安市科技局项目(MS2015026)
