摘要
赖氨酸锗(Ge401)是国内新近研制的含微量元素锗有机物。测得小鼠gi LD_(50)为9.26g/kg,ip LD_(50)为5.62g/kg;采用ig、ip、iv途径给药,对小鼠S-180肉瘤均有显著抑瘤作用,其中iv给药的抑瘤率(55%)最高;Ge401(30mg/kg·5d^(-1))和环磷酰胺(30mg/kg·2d^(-1))合用具有明显增强抑瘤作用。
Lysine-germanium ( Ge401 ) was a newly synthesized organoger-manium compound in China. The LD50 of Ge401 for mice was 9.26 and 5.62 g/kg po and ip administrations. The inhibition rates of subcutaneously transplanted S-180 sarcoma in mice were 25%, 32% and 55% respectively when ip, po and iv administrations of Ge401 were used. The antitumor activity of cyclophosphamide (30 mg/kg· 2d-1, ip ) in S-180 bearing mice was significantly potentiated by Ge401 (30 mg/kg·d-1, iv ) .
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第1期32-35,共4页
Chinese Pharmacological Bulletin
关键词
赖氨酸锗
环磷酰胺
抑瘤作用
Trace element
Lysine-germanium
S-180 sarcoma
Cyclophosphamide
Antitumor effect
