摘要
目的检测闭合性颅脑损伤患者血清中S100-β蛋白水平,分析其对该病诊断及预后评估的临床价值。方法采用免疫定量分析法检测31例健康对照组、40例重型颅脑损伤患者和34例轻型颅脑损伤患者入院时S100-β蛋白水平、受试者工作特征曲线(ROC)、预后GOS相关性分析,探讨其对闭合性颅脑损伤的辅助诊断效能。结果对照组、轻型及重型闭合性颅脑损伤组S100-β蛋白水平分别为0.137±0.025,0.192±0.038和0.276±0.097ng/ml。与对照组相比,轻型(F=0.126,P=0.008)及重型闭合性颅脑损伤组(F=38.17,P=0.001)血清S100-β蛋白水平均显著升高,差异有统计学意义(P<0.01)。轻型与重型颅脑损伤组间血清S100-β水平差异有统计学意义(P<0.05)。血清S100-β蛋白鉴别对照组与轻型颅脑损伤组的AUC为0.870(95%CI:0.776～0.964,P<0.01);S100-β蛋白鉴别健康对照组与重型颅脑损伤组的AUC为0.914(95%CI:0.850～0.978,P<0.01)。颅脑损伤患者血清S100-β蛋白水平与预后GOS评分呈负相关(r=-0.792,P<0.01)。结论 S100-β蛋白在轻型及重型闭合性颅脑损伤患者血清中显著升高,且与预后GOS评分呈负相关,可用于颅脑损伤的辅助诊断及预后评估。
Objective To detect the level of S100-β protein in the serum of patients with closed craniocerebral injury and ana- lyze its clinical value to assess the diagnosis and prognosis of the disease. Methods The expression of quantitative analysis method to detect 31 cases of healthy control group, 40 cases of patients with severe craniocerebral injury and 34 cases of craniocerebral injury patients on admission S100-13 protein level by the receiver operating characteristic curve （ROC） analy- sis,t0 explore the correlation between the prognosis of GOS,closed craniocerebral injury diagnosis efficacy. Results In the control group, mild and severe closed craniocerebral injury group S100-13 protein levels were 0. 137 ± 0. 025,0. 192 ±0. 038 and 0. 276± 0. 097 ng/ml, respectively. Compared with the control group （F= 0. 126, P = 0. 008）, light and heavy closed craniocerebral injury group （F= 38.17, P= 0. 001） of serum S100-β protein levels were significantly increased, the difference was statistically significant （P〈 0.01）. There were significant differences in the level of serum S100-β light and heavy craniocerebral injury group （P〈0.05）. Serum S100-13protein differential control group and brain injury group AUC 0. 870 （95 %CI：0. 776-0. 964, P〈~0.01）. $100-13 protein identification in healthy control group with severe craniocerebral injury group AUC was 0.914 （95 % CI ： 0. 850 - 0. 978, P〈 0.01）. The score was negatively correlated with serum $100-13 protein level and the prognosis of craniocerebral injury in GOS （r=-0. 792,P〈0.01）. Conclusion S100-I3 protein significantly in- creased in serum of light and heavy closed craniocerebral injury patients, and negatively correlated with the GOS score of pa- tients,can be used for the auxiliary diagnosis and prognosis of craniocerebral injury.
出处
《现代检验医学杂志》
CAS
2017年第5期59-61,共3页
Journal of Modern Laboratory Medicine
基金
陕西省科学技术研究发展计划[2011K12-76]
西安市科技局科学发展计划项目[2016046SF/YX02(3)]
