摘要
目的探讨不同抗菌治疗方案对老年糖尿病合并肺部感染患者血清学指标和疗效的影响。方法选取医院2014年4月-2016年2月应用头孢他啶联合氨溴索治疗的58例老年糖尿病合并肺部感染患者为观察组,头孢噻肟钠联合氨溴索治疗的60例患者作为对照组,比较两组用药前后血清学指标的变化,同时在用药10d后对疗效和药物不良反应。结果治疗后两组血清内皮素(ET)、C-反应蛋白(CRP)、白细胞计数(WBC),降钙素基因相关肽(CGRP)与治疗前差异有统计学意义(P<0.05),观察组CD_4^+/CD_8^+明显改善,对照组CD_4^+/CD_8^+无明显改善,治疗后观察组ET、CRP、WBC、CGRP、CD_4^+/CD_8^+分别为(41.63±5.17)ng/L、(51.39±8.67)mg/L、(8.37±4.25)×10~9/L、(67.53±5.43)ng/L、(1.56±0.23)表达水平显著优于对照组(58.37±6.03)ng/L、(87.69±8.75)mg/L、(11.68±4.37)×10~9/L、(50.34±4.56)ng/L、(1.04±0.15)(P<0.05);观察组总有效率为82.76%显著高于对照组66.67%(P<0.05);观察组并发症发生率为8.62%明显低于对照组16.67%(P<0.05)。结论头孢他啶联合氨溴索作为广谱杀菌方案,不仅能显著抑制血清炎性因子表达,能有益调节免疫功能。
OBJECTIVE To observe and analyze the effects of different antimicrobial therapy regimens on serum markers and curative effect of elderly patients with diabetes mellitus complicated with pulmonary infections.METHODS A total of 58 patients with senile diabetes mellitus complicated with pulmonary infections who were treated with ceftazidime combined with ambroxol in our hospital from Apr.2014 to Feb.2016 were selected as observation group,and 60 patients treated with cefotaxime sodium combined with ambroxol were set as control group.The changes of serum markers of the two groups before and after treatment were compared,while the efficacy and adverse drug reactions 10 days after treatment were compared.RESULTS After treatment,the levels of serum ET,CRP and WBC and CGRP had significant differences with those before treatment（P0.05）.CD_4~＋/CD_8~＋ were significantly improved in observation group and CD_4~＋/CD_8~＋ in control group had no significant improvement.The levels of ET,CRP,WBC,CGRP,and CD_4~＋/CD_8~＋ in observation group after treatment were（41.63 ± 5.17）ng/L,（51.39 ± 8.67）mg/L,（8.37 ± 4.25）×10~9/L,（67.53 ± 5.43）ng/L,and（1.56±0.23）,which were significantly higher than（58.37±6.03）ng/L,（87.69±8.75）mg/L,（11.68±4.37）×10~9/L,（50.34±4.56）ng/L,and（1.04±0.15）in control group（P0.05）.The total effective rate in observation group was 82.76%,which was significantly higher than 66.67% in control group（P0.05）.The incidence of complications in observation group was 8.62%,which was significantly lower than 16.67% in control group（P0.05）.CONCLUSION Ceftazidime combined with ambroxol as a broad-spectrum bactericidal regimen not only significantly inhibits the expression of inflammatory cytokines,but also has a beneficial regulatory effect on immune function.
作者
史荣
冯飞
陈袁
谢文娅
邱小丽
翁恍
SHI Rong FENG Fei CHEN Yuan XIE Wen-ya QIU Xiao-li WENG Huang(The First People＇s Hospital of Zunyi, Zunyi, Guizhou 563002, Chin)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第20期4645-4648,共4页
Chinese Journal of Nosocomiology
关键词
抗菌治疗
老年糖尿病
肺部感染
血清学指标
Antibacterial treatment
Senile diabetes
Pulmonary infection
Serological indicators
