摘要
非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是西方国家及一些亚洲国家中常见的慢性肝脏疾病,目前在世界范围内的发病率逐渐上升。NAFLD包括单纯性脂肪肝、非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)、NASH相关性肝硬化及肝癌等一系列疾病。NASH进展为肝硬化、肝癌的风险大,预后差,是世界范围内沉重的医疗负担。NAFLD是由多种因素引起的疾病,除了环境因素及遗传因素外,近年来不断有证据提示,肠道菌群在NAFLD的发生、发展过程中起一定作用,本文就肠道菌群与NAFLD关系的研究进展作一概述。
Non-alcoholic fatty liver disease（ NAFLD） is a common chronic liver disease in Western countries and some Asian countries,and currently the incidence of NAFLD continues to increase worldwide. NAFLD encompasses a pathologic spectrum of disease,from relatively benign accumulation of lipid（ steatosis） to progressive non-alcoholic steatohepatitis（ NASH） associated with inflammation,fibrosis,necrosis and hepatocellular carcinoma. Without an effective available treatment,the prognosis of NASH is poor due to the high risk of progressive liver diseases such as cirrhosis and carcinoma,making it a great burden in health worldwide. NAFLD is a multifactorial disease,apart from environmental and genetical factors,recent studies suggest that gut microbiota might be implicated in the pathogenesis of NAFLD.Here,the relationship between gut microbiota and NAFLD was reviewed.
出处
《胃肠病学和肝病学杂志》
CAS
2017年第10期1103-1106,共4页
Chinese Journal of Gastroenterology and Hepatology
关键词
肠道菌群
非酒精性脂肪性肝病
胰岛素抵抗
Gut microbiota
Non-alcoholic fatty liver disease
Insulin resistance
