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循环肿瘤细胞与可手术乳腺癌预后相关性的meta分析 被引量:2

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摘要 目的运用meta分析的方法对可手术乳腺癌患者外周血循环肿瘤细胞(CTCs)与预后的相关性进行系统分析。方法收集有关CTCs与可手术乳腺癌预后关系的文献,用风险比(HR)及95%置信区间(CI)评价外周血CTCs与可手术乳腺癌预后的关系,采用固定效应模型或随机效应模型计算合并HR及95%CI值,用stata12.0软件进行meta分析。结果共纳入23篇文献,共8 146例可手术乳腺癌患者。总生存率(OS)的HR=2.27(95%CI:1.95~2.64)、无病生存率(DFS)的HR=2.33(95%CI:1.88~2.88),差异具有统计学意义(均P<0.05)。结论可手术乳腺癌患者外周血CTC(+)患者的OS和DFS均低于CTC(-)患者,可手术乳腺癌患者外周血CTCs与预后呈负相关。
出处 《中国老年学杂志》 CAS 北大核心 2017年第20期5079-5082,共4页 Chinese Journal of Gerontology
基金 吉林省科技厅科研基金资助课题(No.20150312033ZG)
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  • 1杨名添,戎铁华,黄植蕃,曾灿光,龙浩,傅剑华,林鹏,王欣,王思愚,王曦,唐军.可手术乳腺癌6263例临床分析[J].癌症,2005,24(3):327-331. 被引量:46
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