摘要
目的:建立贵阳地区育龄人群血红蛋白A_2(HbA_2)筛查轻型β-地中海贫血的截断值。方法:对152例育龄期男性,129例育龄期女性非孕妇和110例孕妇进行血红蛋白电泳和β-地中海贫血基因检测;以基因检测为金标准,绘制Hb A_2的ROC曲线,确定各组HbA_2筛查轻型β-地中海贫血的截断值。结果:整体的截断值为3.95%,敏感度、特异度和准确度分别为94.8%、99.3%和98.5%;男性组的HbA_2截断值(4.40%)明显高于女性非妊娠组(3.75%)和女性妊娠组(3.70%),女性妊娠状态对HbA_2截断值无明显影响。结论:建立了贵阳地区育龄人群HbA_2筛查轻型β-地贫的截断值,不同性别育龄人群的Hb A_2截断值存在差异。
Objective： To determine the cut-off values of hemoglobin A2（ HbA2） screening for mildβ-thalassemia in Guiyang population of reproductive age. Methods： Hemoglobin electrophoresis andβ-thalassemia gene tests were carried out in 152 men of reproductive age,129 non-pregnant women of reproductive age,and 110 pregnant women. With genetic testing as the gold standard,receiver operating characteristic（ ROC） curves of HbA2 were drawnto determine the cut-off values of HbA2 screening for mild β-thalassemia in each group. Results： The overall cut-off valueof HbA2 was 3. 95%,and sensitivity,specificity,accuracy were 94. 8%,99. 3%,98. 5% respectively. The cut-off value of HbA2 in male group（ 4. 40%） was significantly higher than those of female non-pregnancy group（ 3. 75%）and female pregnancy group（ 3. 70%）. Women in pregnancy status had no obvious influence on cutoff value of HbA2. Conclusion： The cut-off values of HbA2 screening for mild β-thalassemia in reproductive population in Guiyang region have been determined. There is certain difference of HbA2 cut-off value in terms of gender,which has a certain guiding significance inscreening for mild β-thalassemia.
作者
韩文平
王树辉
徐琴
杨楠楠
韩媛媛
黄凌
黄盛文
安邦权
HAN Wenping WANG Shuhui XU Qin YANG Nannan HAN Yuanyuan HUANG Ling HUANG Shengwen AN Bangquan(School of Clinical Laboratory Science, Guizhou Medical University, Guiyang 550004, Guizhou , China Department of Clinical Laboratory, People~ Hospital of Guizhou Province, Guiyang 550002, Guizhou, China)
出处
《贵州医科大学学报》
CAS
2017年第10期1121-1124,1129,共5页
Journal of Guizhou Medical University
基金
国家自然科学基金(81660023)
贵州省科学技术厅基础计划[黔科合人才团队(2015)4019号]
贵阳市科技创新平台计划[筑科合同(20161001)35]
