摘要
[目的]:探讨硫普罗宁联合拉米夫定在肺结核合并慢性乙型肝炎患者治疗中的应用效果分析。[方法]选取我院2012年1月~2016年1月收治的90例肺结核合并慢性乙型肝炎患者作为本研究对象,按随机数字表的方法分为3组,包括药物联合组(n=30)、拉米夫定组(n=30)和对照组(n=30),对照组患者接受2 HRZE/4 HR+常规保肝药+维生素C进行治疗,拉米夫定患者组在对照组基础上使用拉米夫定药物进行治疗,药物联合组患者则在拉米夫定的基础上加以使用硫普罗宁药物进行治疗。分别对3组患者的临床症状持续时间、肝功能情况以及血清纤维化指标进行客观的评定和比较。[结果]3组患者经治疗后比较,药物联合组的发热消退时间、咳嗽停止时间、盗汗消退时间等明显更短于其他2组,其中,对照组患者的症状时间最长(P<0.05);3组患者治疗后的ALT、AST、TBIL水平明显下降,低于治疗前,且3组间的ALT、AST、TBIL水平比较有统计学意义,其中药物联合组改善的最为显著(P<0.05);同时,治疗后药物联合组和拉米夫定组患者的各血清纤维化指标(PCIII、IV-C、HA)明显降低(P<0.05),明显更低于对照组,其中药物联合组最低。[结论]硫普罗宁联合拉米夫定治疗肺结核合并慢性乙型肝炎患者可以有效改善患者的不良症状的同时保护肝功能,可以辅助促进短程化疗的疗效,值得推广应用。
[Objective]To investigate the effect of tiopronin combined with lamivudine in the treatment of pulmonary tuberculosis with chronic hepatitis B patients.[Methods]Divided into three groups according to the random number table method,including drug combination group（n=30）,lamivudine group（n=30）and control group（n=30）.The patients in the control group received 2 HRZE/4 HR＋conventional hepatoprotective drug＋vitamin C for treatment.The lamivudine group was treated with lamivudine on the basis of the control group,the drug combination group was treated with tiopronin on the basis of the lamivudine group.The duration of clinical symptoms,liver function and serum fibrosis indexes were compared between the three groups.[Results]Compared with the other two groups,fever subsided time,cough stop time,night sweats subsided time in Drug combination group is significantly shorter than the other two groups,the control group of patients with symptoms of the longest time（P〈0.05）;Three groups of patients after treatment of ALT,AST and TBIL were decreased and lower than those before treatment,and the drug combination group improved the most significant（P〈0.05）;At the same time,the serum fibrosis indexes（PCIII,IV-C,HA）were significantly lower（P〈0.05）in the drug combination group and lamivudine group after treatment,and the drug combination group was the lowest.[Conclusion]Tiopronin combined with lamivudi-ne in the treatment of pulmonary tuberculosis complicated with chronic hepatitis B patients can effectively improve the patient＇s adverse symptoms while protecting liver function and can promote the curative effect of short course chemotherapy,it is worthy of popularization and application.
作者
房爱杰
FANG Ai-jie(Xinghua People＇s Hospital of Jiangsu Province, Xinghua 225700, Chin)
出处
《中国中西医结合消化杂志》
CAS
2017年第9期698-701,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
硫普罗宁
拉米夫定
肺结核
慢性乙型肝炎
肝功能
Tiopronin combined
Lamivudine
tuberculosis
chronic hepatitis b
liver function
