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多西他赛和紫杉醇致严重不良反应比较

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摘要 目的探讨多西他赛与紫杉醇致严重不良反应的特点,为临床治疗用药安全性提供参考依据。方法回顾性分析2010年1月—2017年1月某医院关于多西他赛和紫杉醇致严重不良反应的临床诊断治疗报告42份,多西他赛20份,紫杉醇22份。对比两种药物致不良反应的发生例数、临床表现及特点。结果两种药物致严重不良反应例数中,多西他赛致过敏性休克相较于紫杉醇明显更少;而紫杉醇致过敏性反应和骨髓抑制相较于多西他赛明显更少。两种药物致严重不良反应临床表现及特点中,多西他赛不良反应表现为过敏性休克、过敏性反应、骨髓抑制、白细胞减少、肠胃出血、胸闷和背痛;紫杉醇不良反应表现为过敏性休克、过敏性反应、骨髓抑制、白细胞减少、肠胃出血。在停止用药和采取吸氧、抗过敏等针对性治疗后,患者不良反应症状得到明显改善。结论多西他赛和紫杉醇致严重不良反应的临床表现和特点虽然存在差异性,但必须要对两种药物的用药过程进行用药监护和用药指导,保障用药安全。
作者 王耿
机构地区 山西医科大学
出处 《基层医学论坛》 2017年第28期3927-3928,共2页 The Medical Forum
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