摘要
目的:探讨血管紧张素原(AGT)M235T基因多态性与中国人原发高血压(EH)的相关性。方法:应用聚合酶链反应-限制性内切酶酶解的方法检测132例EH患者和143例正常健康人(对照组)的AGTM235T基因型,比较各组间的基因型及等位基因分布频率差异,分析AGTM235T基因多态性与EH的关系。结果:EH患者AGTM235T基因型MM、MT、TT的频率分别为43.2%、25.5%、31.3%,与正常对照组的53.5%、28.1%、18.4%比较有差异,但无统计学意义(P>0.05);AGTM235T等位基因频率:M正常组67.5%,EH组55.9%;T正常组32.5%,EH组45.1%;T等位基因频率在EH组明显高于正常对照组。结论:AGTM235T的T等位基因频率在EH组的分布较正常组高,AGTM235T基因多态性与EH可能有关,即T等位基因携带可能增加EH发病的危险。
Objectives:To study the association of the angiotensinogen(AGT) gene polymorphism with essential hypertension(EH).Methods:AGT M235T genotype was detected by polymerase chain reaction restriction fragment length polymorphism in 132 patients with EH and 143 healthy subjects.The frequency of AGT M235T genotypes and allels in patients with EH was compared to that in healthy subjects.Results:The frequencies of AGT M235T genotype MM、MT and TT were no statistical difference (P >0.05)between EH(43.2%、25.5%and 31.3% respectively)and healthy subjects(53.5%、28.1% and 18.4% respectively).But we found that the frequency of T allele in EH is higher than that in healthy subjects.Conclusion:The T allele bearer of AGT(M235T) gene may be a genetic risk factor of essential hypertension.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2002年第5期363-364,394,共3页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省科委自然科学基金资助项目(015DC9804)
