摘要
目的建立复方降血脂丸的质量标准。方法对方中丹参、决明子、何首乌、山楂等进行薄层色谱(TLC)鉴别;采用高效液相色谱(HPLC)法对方中君药决明子所含药效成分大黄酚进行含量测定。结果 TLC法斑点显色清晰,重复性、分离度均较好;大黄酚质量浓度在1.91~122.28μg/mL范围内与峰面积线性关系良好,r=0.999 6(n=7);平均加样回收率为108.01%,RSD为1.16%(n=6)。结论该研究中确立的定性、定量检测方法简便易行,重复性好,结果准确可靠,可用于复方降血脂丸的质量控制。
Objective To establish the quality standard of Fufang Jiangxuezhi Pills. Methods TLC method was adopted for the qualitative identification of Salvia miltiorrhizae,Catsia tora,Fallopia multiflora and Crataegus pinnatifida. HPLC method was adopted to determine chrysophanol in Catsia tora. Results TLC spots were clear with good reproducibility and separation. The linear relationship of chrysophanol content was good in the range of 1. 91-122. 28 μg/mL,r=0. 9996 （ n=7）,the average recovery was 108. 01%,and the RSD was 1. 16%（n=6）. Conclusion The qualitative and quantitative method is simple,accurate and reliable,which can be used for quality control of Fufang Jiangxuezhi Pills.
出处
《中国药业》
CAS
2017年第20期25-28,共4页
China Pharmaceuticals
关键词
复方降血脂丸
丹参
决明子
何首乌
山楂
大黄酚
薄层色谱鉴别法
高效液相色谱法
含量测定
质量标准
Fufang Jiangxuezhi Pills
Salvia miltiorrhizae
Catsia tora
Fallopia multiflora
Crataegus pinnatifida
chrysophanol
TLC
HPLC
content determination
quality standard
