摘要
琥珀酸美托洛尔(Metoprolol Succinate)为选择性β1受体阻滞剂,是治疗高血压、冠心病、慢性心力衰竭和心律失常的常用药物.笔者运用一维和二维核磁共振(NMR)波谱技术,对琥珀酸美托洛尔的结构进行了详细的解释,并探讨了溶剂、温度和浓度对其~1H NMR化学位移的影响.发现结构中含有C—N键的化合物,由于氮上的孤对电子和C—N键的旋转使得氮上所连异丙基的两个甲基,出现裂分.当DMSO-d6作为溶剂时,由于琥珀酸美托洛尔中的活泼氢质子与DMSO中硫羰基形成了分子间的氢键,使得N上的孤对电子的影响减弱,两个甲基在同一位置出峰.
Metoprolol Succinate as the selective beta 1 receptor blockers,is one of the commonly drugs to treat high blood pressure,coronary heart disease,chronic heart failure and arrhythmia.The -1H and -（13）C NMR chemical shifts of Metoprolol Succinate were determined by the advanced 1D and 2D Nuclear magnetic resonance（NMR）techniques.The influences of solvent type,solvent concentration,and temperature on the ^1H NMR chemical shifts were investigated.The C—N bond rotational barrier was also investigated.It was found that the methyl groups which are not directly linked to nitrogen appear crack peak.When DMSO-d6 was used as solvent,the active hydrogen protons act with the sulfur carbonyl in DMSO to form intermolecular hydrogen bond.This leads these two methyl groups to produce one peak only.
出处
《浙江工业大学学报》
CAS
北大核心
2017年第5期535-539,共5页
Journal of Zhejiang University of Technology
